Molecular structure of Ac-LEHD-AFC, CAS Number: 210345-03-2
Ac-LEHD-AFC (CAS 210345-03-2)
See product citations (1)
Alternate Names:
Caspase-9 substrate (fluorogenic)
Application:
Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9
CAS Number:
210345-03-2
Purity:
≥96%
Molecular Weight:
765.69
Molecular Formula:
C33H38F3N7O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9. Additionally, Ac-LEHD-AFC is a protein known for its apoptotic properties, specifically in prostate cancer cells. It triggers apoptosis by modulating various factors such as mitochondrial membrane potential, cytosolic calcium levels, and proteolytic activity. Notably, Ac-LEHD-AFC activates the mitochondria-mediated apoptosis pathway by promoting the release of cytochrome c from the mitochondria into the cytosol. Consequently, this mechanism induces DNA fragmentation and eventual cell death.
Ac-LEHD-AFC (CAS 210345-03-2) References
- Calpain activation after mitochondrial permeability transition in microcystin-induced cell death in rat hepatocytes. | Ding, WX., et al. 2002. Biochem Biophys Res Commun. 291: 321-31. PMID: 11846407
- Mitochondrial and endoplasmic reticulum stress-induced apoptotic pathways are activated by 5-aminolevulinic acid-based photodynamic therapy in HL60 leukemia cells. | Grebenová, D., et al. 2003. J Photochem Photobiol B. 69: 71-85. PMID: 12633980
- Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells. | Li, J., et al. 2005. J Neurochem. 92: 462-76. PMID: 15659217
- Molecular mechanisms of apoptosis induced by Scorpio water extract in human hepatoma HepG2 cells. | Kwon, KB., et al. 2005. World J Gastroenterol. 11: 943-7. PMID: 15742393
- Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications. | Fernández, Y., et al. 2005. Cancer Res. 65: 6294-304. PMID: 16024631
- The apoptosome activates caspase-9 by dimerization. | Pop, C., et al. 2006. Mol Cell. 22: 269-75. PMID: 16630894
- Mitochondrion-mediated apoptosis induced by Rana grylio virus infection in fish cells. | Huang, YH., et al. 2007. Apoptosis. 12: 1569-77. PMID: 17551838
- Prunella vulgaris extract and rosmarinic acid prevent UVB-induced DNA damage and oxidative stress in HaCaT keratinocytes. | Vostálová, J., et al. 2010. Arch Dermatol Res. 302: 171-81. PMID: 19862537
- Cysteine protease attribute of eukaryotic ribosomal protein S4. | Sudhamalla, B., et al. 2012. Biochim Biophys Acta. 1820: 1535-42. PMID: 22579920
- Small-Molecule-Induced and Cooperative Enzyme Assembly on a 14-3-3 Scaffold. | den Hamer, A., et al. 2017. Chembiochem. 18: 331-335. PMID: 27897387
- Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme. | Li, Y., et al. 2017. Proc Natl Acad Sci U S A. 114: 1542-1547. PMID: 28143931
- Light-driven release of cucurbit[8]uril from a bivalent cage. | de Vink, PJ., et al. 2021. Chem Sci. 12: 6726-6731. PMID: 34040748
- A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. | Thornberry, NA., et al. 1997. J Biol Chem. 272: 17907-11. PMID: 9218414
Activator of:
urocortin II.Substrate of:
caspase-4, caspase-5, caspase-9, and Fluorogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ac-LEHD-AFC, 5 mg | sc-311277 | 5 mg | $338.00 | |||
Ac-LEHD-AFC, 10 mg | sc-311277A | 10 mg | $669.00 |