Molecular structure of Ac-DEVD-pNA, CAS Number: 189950-66-1
Ac-DEVD-pNA (CAS 189950-66-1)
See product citations (14)
Alternate Names:
N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide; Caspase-3 Substrate (Chromogenic)
Application:
Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases
CAS Number:
189950-66-1
Purity:
≥97%
Molecular Weight:
638.58
Molecular Formula:
C26H34N6O13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) (Km=9.7muM) and related cysteine proteases. It is also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10. The sequence is based on PARP (poly(ADPribose) polymerase) cleavage site Asp216 for caspase-3. Cleavage is monitored colorimetrically at 405nm.
Ac-DEVD-pNA (CAS 189950-66-1) References
- Caspase 3 regulates phosphatidylserine externalization and phagocytosis of oxidatively stressed erythrocytes. | Mandal, D., et al. 2002. FEBS Lett. 513: 184-8. PMID: 11904147
- Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis. | Peterson, QP., et al. 2010. Nat Protoc. 5: 294-302. PMID: 20134429
- Caspase-3 serves as an intracellular immune receptor specific for lipopolysaccharide in oyster Crassostrea gigas. | Xu, J., et al. 2016. Dev Comp Immunol. 61: 1-12. PMID: 26993662
- Nicotinamide phosphoribosyltransferase aggravates inflammation and promotes atherosclerosis in ApoE knockout mice. | Kong, YY., et al. 2019. Acta Pharmacol Sin. 40: 1184-1192. PMID: 30833708
- Protective effects of salvianolic acid B against hydrogen peroxide‑induced apoptosis of human umbilical vein endothelial cells and underlying mechanisms. | Gao, S., et al. 2019. Int J Mol Med. 44: 457-468. PMID: 31173197
- Detection of Superoxide Alterations Induced by 5-Fluorouracil on HeLa Cells with a Cell-Based Biosensor. | Mavrikou, S., et al. 2019. Biosensors (Basel). 9: PMID: 31623083
- A novel Bcl-2 inhibitor, BM-1197, induces apoptosis in malignant lymphoma cells through the endogenous apoptotic pathway. | Sun, YL., et al. 2019. BMC Cancer. 20: 1. PMID: 31892356
- The protective effects of PI3K/Akt pathway on human nucleus pulposus mesenchymal stem cells against hypoxia and nutrition deficiency. | Tian, D., et al. 2020. J Orthop Surg Res. 15: 29. PMID: 31992313
- Mechanism of miR-218-5p in autophagy, apoptosis and oxidative stress in rheumatoid arthritis synovial fibroblasts is mediated by KLF9 and JAK/STAT3 pathways. | Chen, M., et al. 2021. J Investig Med. 69: 824-32. PMID: 33558275
- Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. | Nicholson, DW., et al. 1995. Nature. 376: 37-43. PMID: 7596430
- Interleukin-1 beta converting enzyme. | Thornberry, NA. 1994. Methods Enzymol. 244: 615-31. PMID: 7845238
- Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. | Lazebnik, YA., et al. 1994. Nature. 371: 346-7. PMID: 8090205
- Activation of the CPP32 protease in apoptosis induced by 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents. | Datta, R., et al. 1996. Blood. 88: 1936-43. PMID: 8822910
- Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. | Datta, R., et al. 1997. J Biol Chem. 272: 1965-9. PMID: 8999887
- Substrate specificities of caspase family proteases. | Talanian, RV., et al. 1997. J Biol Chem. 272: 9677-82. PMID: 9092497
Substrate of:
caspase-10, caspase-3, caspase-6, caspase-7, caspase-8, and Chromogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ac-DEVD-pNA, 1 mg | sc-311275 | 1 mg | $97.00 | |||
Ac-DEVD-pNA, 5 mg | sc-311275A | 5 mg | $286.00 | |||
Ac-DEVD-pNA, 25 mg | sc-311275B | 25 mg | $734.00 | |||
Ac-DEVD-pNA, 250 mg | sc-311275C | 250 mg | $4692.00 |