Date published: 2026-4-24

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AC 55649 (CAS 59662-49-6)

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Alternate Names:
4′-Octyl-[1,1′-biphenyl]-4-carboxylic acid
Application:
AC 55649 is a potent, isoform-selective RARβ2 receptor agonist
CAS Number:
59662-49-6
Purity:
≥98%
Molecular Weight:
310.44
Molecular Formula:
C21H26O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

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AC 55649 is a research compound that is of interest in various studies due to its biological activity. It is often used in biochemical assays to understand its interaction with and modulation of cellular pathways. The compound′s mechanism of action, specific targets within cells, and the resulting biological responses are key areas of investigation. AC 55649 is also utilized as a tool compound to dissect signaling networks and to identify potential points of intervention. Research involving AC 55649 may focus on its effects on gene expression, protein function, and cellular processes such as proliferation and differentiation. Additionally, the compound is of interest in the study of its biochemical kinetics and dynamics, which are essential for understanding its behavior within biological systems.


AC 55649 (CAS 59662-49-6) References

  1. Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist.  |  Lund, BW., et al. 2005. J Med Chem. 48: 7517-9. PMID: 16302793
  2. Identification of novel subtype selective RAR agonists.  |  Piu, F., et al. 2005. Biochem Pharmacol. 71: 156-62. PMID: 16303118
  3. Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor.  |  Alvarez, S., et al. 2007. Int J Biochem Cell Biol. 39: 1406-15. PMID: 17433757
  4. Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands.  |  Lund, BW., et al. 2009. J Med Chem. 52: 1540-5. PMID: 19239230
  5. A gene expression-based screening system for compounds influencing differentiation of mouse embryonic stem cells.  |  Kunisada, Y., et al. 2012. J Biomol Screen. 17: 140-51. PMID: 21965112
  6. High content screening for compounds that induce early stages of human embryonic stem cell differentiation.  |  Jee, J., et al. 2012. Comb Chem High Throughput Screen. 15: 656-65. PMID: 22364550
  7. Chemical activation of RARβ induces post-embryonically bilateral limb duplication during Xenopus limb regeneration.  |  Cuervo, R. and Chimal-Monroy, J. 2013. Sci Rep. 3: 1886. PMID: 23703360
  8. Identification of compounds that modulate retinol signaling using a cell-based qHTS assay.  |  Chen, Y., et al. 2016. Toxicol In Vitro. 32: 287-96. PMID: 26820057
  9. A comprehensive map of disease networks and molecular drug discoveries for glaucoma.  |  Wang, H., et al. 2020. Sci Rep. 10: 9719. PMID: 32546683
  10. The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model.  |  Wertman, JN., et al. 2020. Elife. 9: PMID: 32720645
  11. Recent advances in the design of RAR α and RAR β agonists as orally bioavailable drugs. A review.  |  Borthwick, AD., et al. 2020. Bioorg Med Chem. 28: 115664. PMID: 33069074
  12. Predicting Agents That Can Overcome 5-FU Resistance in Colorectal Cancers via Pharmacogenomic Analysis.  |  Huang, TC., et al. 2021. Biomedicines. 9: PMID: 34440086
  13. Involvement of hedgehog signaling in all-trans retinoic acid-mediated suppression of colon cancer.  |  Xu, Y. and Sun, H. 2022. Am J Transl Res. 14: 6536-6549. PMID: 36247302

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

AC 55649, 10 mg

sc-203490
10 mg
$89.00
US: Only available in the US

AC 55649, 50 mg

sc-203490A
50 mg
$369.00
US: Only available in the US