Molecular structure of AC 45594, CAS Number: 13037-86-0
AC 45594 (CAS 13037-86-0)
Application:
AC 45594 is an agonist at the orphan nuclear receptor steroidogenic factor-1
CAS Number:
13037-86-0
Purity:
97%
Molecular Weight:
208.3
Molecular Formula:
C13H20O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
AC 45594 is a selective inverse agonist at the orphan nuclear receptor SF-1 (steroidogenic factor-1) (IC50= 50-100 nM). Displays no activity at estrogen, LRH-1, ROR, ERR or Nurr receptors. Inhibits SFRE-mediated transcription.
AC 45594 (CAS 13037-86-0) References
- Identification of the first synthetic steroidogenic factor 1 inverse agonists: pharmacological modulation of steroidogenic enzymes. | Del Tredici, AL., et al. 2008. Mol Pharmacol. 73: 900-8. PMID: 18055761
- Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists. | Doghman, M., et al. 2009. J Clin Endocrinol Metab. 94: 2178-83. PMID: 19318454
- Identification and characterization of steroidogenic factor-1 inverse agonists. | Doghman, M., et al. 2010. Methods Enzymol. 485: 3-23. PMID: 21050908
- Inverse agonist activity of steroidogenic factor SF-1. | Piu, F. and Del Tredici, AL. 2010. Methods Enzymol. 485: 245-59. PMID: 21050921
- Therapeutic potential of Liver Receptor Homolog-1 modulators. | Lazarus, KA., et al. 2012. J Steroid Biochem Mol Biol. 130: 138-46. PMID: 22266285
- Current and emerging therapeutic options in adrenocortical cancer treatment. | Stigliano, A., et al. 2012. J Oncol. 2012: 408131. PMID: 22934112
- New insights and future perspectives in the therapeutic strategy of adrenocortical carcinoma (Review). | Stigliano, A., et al. 2017. Oncol Rep. 37: 1301-1311. PMID: 28184938
- Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1. | Liu, L., et al. 2019. Liver Int. 39: 2112-2123. PMID: 30664326
- Orphan nuclear receptors as regulators of intratumoral androgen biosynthesis in castration-resistant prostate cancer. | Zhou, J., et al. 2021. Oncogene. 40: 2625-2634. PMID: 33750894
- Systematic In Vitro Evaluation of a Library of Approved and Pharmacologically Active Compounds for the Identification of Novel Candidate Drugs for KMT2A-Rearranged Leukemia. | Karsa, M., et al. 2021. Front Oncol. 11: 779859. PMID: 35127484
Inhibitor of:
SF.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AC 45594, 1 g | sc-203798 | 1 g | $37.00 | |||
AC 45594, 5 g | sc-203798A | 5 g | $77.00 |