Molecular structure of AC 261066, CAS Number: 870773-76-5
AC 261066 (CAS 870773-76-5)
Application:
AC 261066 is a potent RARβ2 agonist
CAS Number:
870773-76-5
Molecular Weight:
353.41
Molecular Formula:
C17H20FNO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AC 261066 has been reported to be a potent RARβ2 agonist. Studies suggest that this compound is selective over RARβ1, RARα and RARγ.
AC 261066 (CAS 870773-76-5) References
- Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. | Lund, BW., et al. 2005. J Med Chem. 48: 7517-9. PMID: 16302793
- Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands. | Lund, BW., et al. 2009. J Med Chem. 52: 1540-5. PMID: 19239230
- Retinoid receptors and therapeutic applications of RAR/RXR modulators. | le Maire, A., et al. 2012. Curr Top Med Chem. 12: 505-27. PMID: 22242853
- Low dose bexarotene treatment rescues dopamine neurons and restores behavioral function in models of Parkinson's disease. | McFarland, K., et al. 2013. ACS Chem Neurosci. 4: 1430-8. PMID: 24117438
- Retinoic acid receptor β2 agonists restore glycaemic control in diabetes and reduce steatosis. | Trasino, SE., et al. 2016. Diabetes Obes Metab. 18: 142-51. PMID: 26462866
- A retinoic acid receptor β2 agonist reduces hepatic stellate cell activation in nonalcoholic fatty liver disease. | Trasino, SE., et al. 2016. J Mol Med (Berl). 94: 1143-1151. PMID: 27271256
- A Retinoic Acid β2-Receptor Agonist Exerts Cardioprotective Effects. | Marino, A., et al. 2018. J Pharmacol Exp Ther. 366: 314-321. PMID: 29907698
- Amelioration of Diabetic Nephropathy Using a Retinoic Acid Receptor β2 Agonist. | Trasino, SE., et al. 2018. J Pharmacol Exp Ther. 367: 82-94. PMID: 30054312
- Effects of AM80 compared to AC261066 in a high fat diet mouse model of liver disease. | Melis, M., et al. 2019. PLoS One. 14: e0211071. PMID: 30677086
- Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury. | Goncalves, MB., et al. 2019. Bioorg Med Chem Lett. 29: 995-1000. PMID: 30792038
- Effect of Specific Retinoic Acid Receptor Agonists on Noise-Induced Hearing Loss. | Kwak, SH., et al. 2019. Int J Environ Res Public Health. 16: PMID: 31527426
- A Retinoic Acid Receptor β 2 Agonist Improves Cardiac Function in a Heart Failure Model. | Tang, XH., et al. 2021. J Pharmacol Exp Ther. 379: 182-190. PMID: 34389654
- A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes. | Melis, M., et al. 2022. Biofactors. 48: 469-480. PMID: 34687254
- A retinoic acid receptor β2 agonist attenuates transcriptome and metabolome changes underlying nonalcohol-associated fatty liver disease. | Tang, XH., et al. 2021. J Biol Chem. 297: 101331. PMID: 34688661
- Dysregulated Retinoic Acid Signaling in the Pathogenesis of Pseudoexfoliation Syndrome. | Zenkel, M., et al. 2022. Int J Mol Sci. 23: PMID: 35682657
Activator of:
RAR beta, RAR beta 2, and RAR gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AC 261066, 10 mg | sc-361098 | 10 mg | $175.00 | |||
AC 261066, 50 mg | sc-361098A | 50 mg | $709.00 |