Molecular structure of ABT 737, CAS Number: 852808-04-9
ABT 737 (CAS 852808-04-9)
See product citations (54)
Alternate Names:
4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4- (dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl] sulfonylbenzamide
Application:
ABT 737 is a selective inhibitor of Bcl-2
CAS Number:
852808-04-9
Purity:
≥98%
Molecular Weight:
813.43
Molecular Formula:
C42H45ClN6O5S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ABT 737 is a small-molecule that acts as a selective inhibitor of Bcl-2. Bcl-2 proteins play an important role in cell survival and have been shown to be overexpressed in many tumors. By mimicking BH3-only proteins, ABT 737 specifically binds to and inhibits the anti-apoptotic functions of several members of the BCL-2 family, including BCL-2, BCL-xL, and BCL-w, but not MCL-1. ABT 737 also inhibits Bcl-w and Bcl-xl. Studies have reported that ABT 737 effectively kills acute myeloid leukemia blast, progenitor, and stem cells without affecting normal hematopoietic cells. Peripheral blood CLL cells in vitro are also extremely sensitive to ABT 737 (EC50 ~7 nM).
ABT 737 (CAS 852808-04-9) References
- Phase I study of G3139, a bcl-2 antisense oligonucleotide, combined with carboplatin and etoposide in patients with small-cell lung cancer. | Rudin, CM., et al. 2004. J Clin Oncol. 22: 1110-7. PMID: 15020613
- Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. | Konopleva, M., et al. 2006. Cancer Cell. 10: 375-88. PMID: 17097560
- The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan. | Trudel, S., et al. 2007. Clin Cancer Res. 13: 621-9. PMID: 17255285
- ABT-737, proving to be a great tool even before it is proven in the clinic. | Vaux, DL. 2008. Cell Death Differ. 15: 807-8. PMID: 18408737
- ABT-737 sensitizes curcumin-induced anti-melanoma cell activity through facilitating mPTP death pathway. | Yu, T., et al. 2015. Biochem Biophys Res Commun. 464: 286-91. PMID: 26116776
- ABT-737, a Bcl-2 Selective Inhibitor, and Chloroquine Synergistically Kill Renal Cancer Cells. | Yin, P., et al. 2016. Oncol Res. 24: 65-72. PMID: 27178823
- Aspirin restores ABT-737-mediated apoptosis in human renal carcinoma cells. | Ou, YC., et al. 2018. Biochem Biophys Res Commun. 502: 187-193. PMID: 29792865
- ABT-737 ameliorates docetaxel resistance in triple negative breast cancer cell line. | Hwang, E., et al. 2018. Ann Surg Treat Res. 95: 240-248. PMID: 30402442
- ABT‑737, a Bcl‑2 family inhibitor, has a synergistic effect with apoptosis by inducing urothelial carcinoma cell necroptosis. | Cheng, R., et al. 2021. Mol Med Rep. 23: PMID: 33786632
- ABT-737, a BH3 Mimetic, Enhances the Therapeutic Effects of Ionizing Radiation in K-ras Mutant Non-Small Cell Lung Cancer Preclinical Model. | Lee, JM., et al. 2022. Yonsei Med J. 63: 16-25. PMID: 34913280
- ABT-737 suppresses aberrant Hedgehog pathway and overcomes resistance to smoothened antagonists by blocking Gli. | Huang, W., et al. 2022. Med Oncol. 39: 188. PMID: 36071246
- Expression of bcl-2 in small cell lung carcinoma cells. | Ikegaki, N., et al. 1994. Cancer Res. 54: 6-8. PMID: 8261463
- Expression of bcl-2--protein in small cell lung cancer. | Kaiser, U., et al. 1996. Lung Cancer. 15: 31-40. PMID: 8865121
Inhibitor of:
4930539E08Rik, AIFL, Apg-1, Baxα, Bcl-2, Bcl-7c, Bcl-9L, Bcl-B, Bcl-G, Bcl-rambo, Bcl-w, Bcl-xl, BCLP, Bclp2, Bfk, BID, DEDD2, FLASH, GOLT1B, HGTD-P, Hrk, NBK, NOXA, Programmed cell death (PDCD), PUMA, Silg111, ZBTB44, and ZMAT4.Activator of:
Apoptotic Myeloid Marker, Bax, Bcl-B, Bcl-w, Bcl-xL, BCL2L12, Bok, caspase-7, caspase-9, EDRF1, RAIDD, scotin, Smac, Tom20, and Toso.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ABT 737, 2.5 mg | sc-207242 | 2.5 mg | $200.00 |