Molecular structure of ABT 724 trihydrochloride, CAS Number: 70006-24-5
ABT 724 trihydrochloride (CAS 70006-24-5)
Alternate Names:
2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole trihydrochloride
Application:
ABT 724 trihydrochloride is a potent dopamine D4 receptor agonist
CAS Number:
70006-24-5
Purity:
>99%
Molecular Weight:
402.75
Molecular Formula:
C17H19N5•3HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
ABT 724 trihydrochloride is a selective D4DR (dopamine D4 receptor) partial agonist with an EC50=12.4nM. It is known that ABT 724 trihydrochloride aids sildenafil′s ability to inhibit cGMP-specific phosphodiesterase type 5. cGMP-specific phosphodiesterase type 5 catalyzes the hydrolysis of 3#39,5#39-cyclic guanosine monophosphate (cGMP). As a result ABT 724 trihydrochloride increases intracavernosal pressure. Studies suggest that sildenafil can enhance neuro-, synapto- and angiogenesis in rat models of stroke, via its ability to increase vasodilation.
ABT 724 trihydrochloride (CAS 70006-24-5) References
- Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. | Stewart, AO., et al. 2004. J Med Chem. 47: 2348-55. PMID: 15084133
- Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. | Brioni, JD., et al. 2004. Proc Natl Acad Sci U S A. 101: 6758-63. PMID: 15087502
- Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction. | Cowart, M., et al. 2004. J Med Chem. 47: 3853-64. PMID: 15239663
- D4 Dopamine receptor genes of zebrafish and effects of the antipsychotic clozapine on larval swimming behaviour. | Boehmler, W., et al. 2007. Genes Brain Behav. 6: 155-66. PMID: 16764679
- Cutting Edge: Stimulation of dopamine D4 receptors induce T cell quiescence by up-regulating Kruppel-like factor-2 expression through inhibition of ERK1/ERK2 phosphorylation. | Sarkar, C., et al. 2006. J Immunol. 177: 7525-9. PMID: 17114421
- Dopamine and T cells: dopamine receptors and potent effects on T cells, dopamine production in T cells, and abnormalities in the dopaminergic system in T cells in autoimmune, neurological and psychiatric diseases. | Levite, M. 2016. Acta Physiol (Oxf). 216: 42-89. PMID: 25728499
- Dopamine D4 receptor antagonist inhibits melanogenesis through transcriptional downregulation of MITF via ERK signalling. | Jung, JM., et al. 2016. Exp Dermatol. 25: 325-8. PMID: 26782007
Inhibitor of:
D4DR.Activator of:
D4DR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ABT 724 trihydrochloride, 10 mg | sc-203489 | 10 mg | $153.00 | |||
| US: Only available in the US | ||||||
ABT 724 trihydrochloride, 25 mg | sc-203489A | 25 mg | $334.00 | |||
| US: Only available in the US | ||||||