Molecular structure of ABT 263, CAS Number: 923564-51-6
ABT 263 (CAS 923564-51-6)
See product citations (16)
Alternate Names:
Navitoclax
Application:
ABT 263 is an inhibitor of antiapoptotic Bcl-2 proteins
CAS Number:
923564-51-6
Purity:
≥98%
Molecular Weight:
974.61
Molecular Formula:
C47H55ClF3N5O6S3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
ABT 263 was designed to mimic the natural binding partner of B-cell lymphoma 2 (BCL-2) proteins. It functions by selectively binding to and inhibiting the activity of the antiapoptotic BCL-2 proteins. In many types of cancer, overexpression of BCL-2 proteins contributes to cancer cell survival to survive and proliferation. By effectively blocking these proteins, ABT 263 exerts its ability to trigger apoptosis specifically in cancer cells. In vitro studies have substantiated its dose-dependent inhibition of cancer cell growth.
ABT 263 (CAS 923564-51-6) References
- Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood. | Vogler, M., et al. 2010. Clin Cancer Res. 16: 4217-25. PMID: 20601444
- Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors. | Gandhi, L., et al. 2011. J Clin Oncol. 29: 909-16. PMID: 21282543
- Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL. | Shi, J., et al. 2011. Cancer Res. 71: 4518-26. PMID: 21546570
- ABT-263 sensitizes TRAIL-resistant hepatocarcinoma cells by downregulating the Bcl-2 family of anti-apoptotic protein. | Wang, G., et al. 2012. Cancer Chemother Pharmacol. 69: 799-805. PMID: 22037880
- Discovery of ABT-263, a Bcl-family protein inhibitor: observations on targeting a large protein-protein interaction. | Wendt, MD. 2008. Expert Opin Drug Discov. 3: 1123-43. PMID: 23506184
- p62/sequestosome-1 up-regulation promotes ABT-263-induced caspase-8 aggregation/activation on the autophagosome. | Huang, S., et al. 2013. J Biol Chem. 288: 33654-33666. PMID: 24121507
- Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263. | Shao, H., et al. 2013. Mol Cancer Ther. 12: 2640-50. PMID: 24126433
- Mechanism-based pharmacokinetic/pharmacodynamic meta-analysis of navitoclax (ABT-263) induced thrombocytopenia. | Kaefer, A., et al. 2014. Cancer Chemother Pharmacol. 74: 593-602. PMID: 25053389
- Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer. | Faber, AC., et al. 2015. Proc Natl Acad Sci U S A. 112: E1288-96. PMID: 25737542
- Bcl-2 phosphorylation confers resistance on chronic lymphocytic leukaemia cells to the BH3 mimetics ABT-737, ABT-263 and ABT-199 by impeding direct binding. | Song, T., et al. 2016. Br J Pharmacol. 173: 471-83. PMID: 26493374
- Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis. | Lagares, D., et al. 2017. Sci Transl Med. 9: PMID: 29237758
- Synergistic anti-proliferative effects of combination of ABT-263 and MCL-1 selective inhibitor A-1210477 on cervical cancer cell lines. | Lian, BSX., et al. 2018. BMC Res Notes. 11: 197. PMID: 29580266
- The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice. | Sharma, AK., et al. 2020. Front Cell Dev Biol. 8: 354. PMID: 32509782
- Bcl-2/Bcl-xL inhibitor ABT-263 overcomes hypoxia-driven radioresistence and improves radiotherapy. | Ritter, V., et al. 2021. Cell Death Dis. 12: 694. PMID: 34257274
Inhibitor of:
Apoptosis, Apoptosis Repressor with CARD (ARC), ARFGAP3, Bcl-2, Bcl-7c, Bcl-G, Bcl-xl, BCLP, Bfk, BNIP-3, CDSN, DNLC2A, FLASH, GOLT1B, GP2, HAX-1, Hrk, LOC100041218, MOMP, Programmed cell death (PDCD), PUMA, and SEC23A.Activator of:
Bax, Bcl-2, Bcl-B, Bcl-w, Bok, caspase-7, scotin, and TP53TG5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ABT 263, 5 mg | sc-207241 | 5 mg | $240.00 |