Molecular structure of ABT-199, CAS Number: 1257044-40-8
ABT-199 (CAS 1257044-40-8)
See product citations (10)
Alternate Names:
ABT-199 is also known as GDC-0199.
Application:
ABT-199 is a BH3 mimetic and a Bcl-2-selective inhibitor with a subnanomolar affinity Ki of <0.01 nM.
CAS Number:
1257044-40-8
Purity:
≥98%
Molecular Weight:
868.44
Molecular Formula:
C45H50ClN7O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
ABT-199 is extensively used in research focusing on its role in targeting B-cell lymphoma 2 (BCL-2) proteins. This compound is for studies investigating the mechanisms of apoptosis in cancer cells, where it acts by selectively inhibiting BCL-2, promoting cell death in tumor cells while sparing healthy cells. Research involving ABT-199 often aims to understand its effects on cellular pathways that lead to cancer cell survival and proliferation. Additionally, ABT-199 is used in studies examining its potential to enhance the efficacy of other cancer research strategies. Furthermore, investigations into the specificity and binding affinity of ABT-199 provide insights into the design of more effective cancer research tools.
ABT-199 (CAS 1257044-40-8) References
- ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. | Souers, AJ., et al. 2013. Nat Med. 19: 202-8. PMID: 23291630
- ABT-199: taking dead aim at BCL-2. | Davids, MS. and Letai, A. 2013. Cancer Cell. 23: 139-41. PMID: 23410971
- Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition. | Tamaki, H., et al. 2014. Oncotarget. 5: 11399-412. PMID: 25333266
- BCL2 inhibitor ABT-199 and BCL2L1 inhibitor WEHI-539 coordinately promote NOXA-mediated degradation of MCL1 in human leukemia cells. | Chiou, JT., et al. 2022. Chem Biol Interact. 361: 109978. PMID: 35561756
- Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia. | Kuusanmäki, H., et al. 2023. Blood. 141: 1610-1625. PMID: 36508699
- Predictors of response to venetoclax plus hypomethylating agent therapy and survival in blast-phase myeloproliferative neoplasm. | Gangat, N., et al. 2022. Haematologica.. PMID: 36519330
- Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model. | Tsuzuki, H., et al. 2022. Oncotarget. 13: 1359-1368. PMID: 36537913
- Persistent splenomegaly due to littoral cell angiomatosis in venetoclax-induced undetectable minimal residual disease of chronic lymphocytic leukemia. | Cellini, A., et al. 2023. Ann Hematol. 102: 681-682. PMID: 36542103
- JAK-STAT signalling shapes the NF-κB response in CLL towards venetoclax sensitivity or resistance via Bcl-XL. | Haselager, MV., et al. 2022. Mol Oncol.. PMID: 36550750
- DNA hypermethylation-induced miR-182 silence targets BCL2 and HOXA9 to facilitate the self-renewal of leukemia stem cell, accelerate acute myeloid leukemia progression, and determine the sensitivity of BCL2 inhibitor venetoclax. | Ye, S., et al. 2023. Theranostics. 13: 77-94. PMID: 36593968
Inhibitor of:
1110018J18Rik, 1110020G09Rik, 1110028C15Rik, 1110032F04Rik, 1110035M17Rik, 1110038F14Rik, 2810426N06Rik, 2900053A13Rik, 4922501L14Rik, 4930408F14Rik, 4930539E08Rik, 4930558K02Rik, 5830482F20Rik, 9330159F19Rik, AI987662, AIFL, apoL11a, ASCL4, ATP5H, B Cell Marker, Barhl1, BC089597, Bcl-2, Bcl-6b, Bcl-7b, Bcl-7c, Bcl-B, Bcl-G, Bcl-rambo, BCL2L12, BCLP, Bclp2, Bfk, BUD31, BZW1, C11orf49, C12orf24, C12orf34, C14orf93, C1orf122, C1orf150, C1orf227, C2orf29_D1Bwg0212e, C330019G07Rik, C330019L16Rik, C330021F23Rik, C6orf182_2410017P07Rik, C9orf103, CCDC82, CD45, CD79A, CD79B, Cid, CMBL, COA1, DENND3, DKFZp761E198, DLD, DLEU7, DLST, DNAH14, DNB5, DNHL1, DNLC2A, DOCK 10, DOCK 5, E47, ENT1, Eos, ERVMER34-1, EVA1A, Evx-1, FAM104A, FAM131B, FAM75D1, FAM90A1, FASTKD1, FASTKD2, FLASH, FLJ34931_BC027072, FLJ39531, FLJ44815, Gight chain, Gm19402, GP2, Hairy Cell Leukemia Marker, HDHD2, HOOK2, Hrk, Ig κ, Ig κ chain, Ig λ, Ig λ chain V4A, IgD Chain, IgD Chain C, IgH, Igk-C, IL-2R, ING4, ISG20L1, LAT2, LOC100040158, LOC100041202, LOC100041214, LOC100041218, LOC100041226, LOC100041229, LOC100041238, LOC100041243, LOC100041261, LOC100041282, LOC100041319, LOC100041434, LOC100041436, LOC100041448, LOC100041465, LOC340094, LOC388237, LOC440330, LOC645478, LOC646823, LOC727862, LOC727992, LOC729103, LOC729521, LOC729729, LOC730111, LOC730198, LOC730205, LOC730223, LPLUNC4, MAGE-D4B, MAML3, MerTK, MLSN1, MOMP, MS4A6A, MSLNL, MTERF, Mtif3, MUM1, MYCBP, NOXA, Olfr1053, Olfr209, Olr1029, Olr1052, Olr1060, Olr111, Olr1124, Olr113, Olr1155, Olr1156, Olr119, Olr1204, Olr1245, Olr125, Olr129, Olr1292, Olr1334, Olr1353, Olr1384, Olr144, Olr1564, Olr159, Olr160, Olr163, Olr1642, Olr1657, Olr168, Olr1718, Olr1733, Olr1739, Olr180, Olr232, Olr307, Olr367, Olr374, Olr410, Olr440, Olr496, Olr526, Olr530, Olr559, Olr560, Olr561, Olr575, Olr592, Olr607, Olr608, Olr649, Olr672, Olr696, Olr714, Olr734, Olr742, Olr749, Olr768, Olr773, Olr775, Olr788, Olr838, PATE-N, Per1, PILR-β, PITHD1, POLA2, Ppp2r3d, Programmed cell death (PDCD), Protein tyrosine phosphatase receptor (PTPR), PUMA, Rag D, RASSF10, RBM24, RBMXL3, RBMY1A, RBQ-1, RHAMM, Rhox3, ROPN1, RPRC1, SCAPER, SCFD1, Sdt, Siglec-G, Silg111, Smac, Sp2, SPANX-A-E, SPDYE2L, TMC3, Tmem217, Top3, TPCN1, TRAP220, Trav12d-1, TRIL, TTYH1, UMPS, UNC93B1, UNQ9438, V1RD10, V1RD20, VAC14, VHY, VpreB1, YPEL, ZBTB24, and ZNF772.Activator of:
AIFL, Apoptotic Myeloid Marker, Bcl-2, Bcl-B, Bcl-w, Bcr, Bim EL, BOB_GPR15, Bok, BXDC2, C19orf62_5430437P03Rik, caspase-7, CED-9, ICAD, IgM, MLLT11, scotin, TACI, and Tom6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ABT-199, 1 mg | sc-472284 | 1 mg | $116.00 | |||
ABT-199, 5 mg | sc-472284A | 5 mg | $330.00 | |||
ABT-199, 10 mg | sc-472284B | 10 mg | $510.00 | |||
ABT-199, 100 mg | sc-472284C | 100 mg | $816.00 | |||
ABT-199, 3 g | sc-472284D | 3 g | $1632.00 |