ABN-CBD CAS: 22972-55-0
MF: C21H30O2
MW: 314.47
An agonist of the novel cannabinoid receptor GPR55.

ABN-CBD (CAS 22972-55-0)

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Alternate Names: Abnormal-cannabidiol
Application: ABN-CBD is an agonist of the novel cannabinoid receptor GPR55
CAS Number: 22972-55-0
Purity: ≥98%
Molecular Weight: 314.47
Molecular Formula: C21H30O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

ABN-CBD is a neurobehaviorally inactive cannabinoid that acts as a selective agonist for GPR55 (EC50 values are 2.5, >30 and >30 μM at GPR55, CB1 and CB2 receptors respectively). ABN-CBD increases the phosphorylation of protein kinases in, and migration of, human umbilical vein endothelial cells.


References

1. Jarai, Z., et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 14136-14141. PMID: 10570211
2. Ho. W.S. and Hiley, C.R., 2003. Br. J. Pharmacol. 138: 1320-1332. PMID: 12711633
3. Mo, F.M., et al. 2004. Eur. J. Pharmacol. 489: 21-27. PMID: 15063151
4. Ryberg, E., et al. 2007. Br. J. Pharmacol. 152: 1092-1101.PMID: 17876302

Formulation :
A solution in methyl acetate
Physical State :
Liquid
Solubility :
Soluble in methyl acetate, ethanol (~35 mg/ml), DMSO (~35 mg/ml), DMF (~35 mg/ml), and DMSO:PBS (1:3, pH 7.2) (0.25 mg/ml).
Storage :
Desiccate at -20° C
Boiling Point :
57° C
Refractive Index :
n20D 1.55 (Predicted)
Optical Activity :
α20/D -71.8°, c = 0.98 in chloroform
IC50 :
regulate the migratory activity of murine BV-2 microglial cells: EC5050 = 0.6 µM; GPR55: EC5050 = 2.5 µM; CB2 : EC5050 >30 µM; CB1 : EC5050 >30 µM
pK Values :
pKa: 9.95 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
VH1620000
PubChem CID :
89949
MDL Number :
MFCD08705633
SMILES :
CCCCCC1=CC(=CC(=C1[[email protected]@H]2C=C(CC[[email protected]]2C(=C)C)C)O)O

Download SDS (MSDS)

Certificate of Analysis

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