Abiraterone-d4 (CAS 2122245-62-7)
Alternate Names:
(3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol-d4
CAS Number:
2122245-62-7
Molecular Weight:
353.53
Molecular Formula:
C24H27D4NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Abiraterone-d4 is a deuterated analog of abiraterone. This modification is designed to explore the pharmacokinetics, metabolism, and biochemical pathways involving abiraterone without altering its fundamental biochemical activity. The presence of deuterium atoms can slow down the metabolic degradation of the molecule, providing insights into how the parent compound interacts within biological systems over time. Abiraterone acts as an inhibitor for several enzymes including CYP17A1, 3β-hydroxysteroid dehydrogenase (3βHSD), and steroid-5α-reductase (SRD5A).
Abiraterone-d4 (CAS 2122245-62-7) References
- A phase I, open-label, single-dose, mass balance study of 14C-labeled abiraterone acetate in healthy male subjects. | Acharya, M., et al. 2013. Xenobiotica. 43: 379-89. PMID: 23020788
- Rapid conversion of the ester prodrug abiraterone acetate results in intestinal supersaturation and enhanced absorption of abiraterone: in vitro, rat in situ and human in vivo studies. | Stappaerts, J., et al. 2015. Eur J Pharm Biopharm. 90: 1-7. PMID: 25592324
- The Effect of Food on the Intraluminal Behavior of Abiraterone Acetate in Man. | Geboers, S., et al. 2016. J Pharm Sci. 105: 2974-2981. PMID: 27061460
- Development and validation of a novel LC-MS/MS method for simultaneous determination of abiraterone and its seven steroidal metabolites in human serum: Innovation in separation of diastereoisomers without use of a chiral column. | Alyamani, M., et al. 2017. J Steroid Biochem Mol Biol. 172: 231-239. PMID: 27063554
- Quantitation of the anticancer drug abiraterone and its metabolite Δ(4)-abiraterone in human plasma using high-resolution mass spectrometry. | Bhatnagar, A., et al. 2018. J Pharm Biomed Anal. 154: 66-74. PMID: 29533860
- Evaluation of reference-scaled average bioequivalence of two oral formulations of abiraterone acetate in healthy Chinese subjects . | Li, C., et al. 2018. Int J Clin Pharmacol Ther. 56: 562-570. PMID: 30220293
- Bioanalytical evaluation of dried plasma spots for monitoring of abiraterone and ∆(4)-abiraterone from cancer patients. | Bhatnagar, A., et al. 2019. J Chromatogr B Analyt Technol Biomed Life Sci. 1126-1127: 121741. PMID: 31421381
- Preclinical evaluation of new formulation concepts for abiraterone acetate bioavailability enhancement based on the inhibition of pH-induced precipitation. | Boleslavská, T., et al. 2020. Eur J Pharm Biopharm. 151: 81-90. PMID: 32298757
- Evaluating bioanalytical capabilities of paper spray ionization for abiraterone drug quantification in patient plasma. | Bhatnagar, A., et al. 2020. J Mass Spectrom. 55: e4584. PMID: 32725840
- Bioavailability Enhancement and Food Effect Elimination of Abiraterone Acetate by Encapsulation in Surfactant-Enriched Oil Marbles. | Boleslavská, T., et al. 2020. AAPS J. 22: 122. PMID: 32978690
- Pharmacokinetic Variability in Pre-Clinical Studies: Sample Study with Abiraterone in Rats and Implications for Short-Term Comparative Pharmacokinetic Study Designs. | Královičová, J., et al. 2022. Pharmaceutics. 14: PMID: 35336017
- Investigating the Mechanisms behind the Positive Food Effect of Abiraterone Acetate: In Vitro and Rat In Situ Studies. | Braeckmans, M., et al. 2022. Pharmaceutics. 14: PMID: 35631538
- Correlation Between Trough Level of Abiraterone and Prostate-Specific Antigen (PSA) Response in Metastatic Hormone-Sensitive Prostate Cancer. | Myint, ZW., et al. 2022. Med Sci Monit. 28: e938091. PMID: 36229939
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Abiraterone-d4, 1 mg | sc-479397 | 1 mg | $850.00 |