ABCC11 Antibody (4H6): sc-517150

ABCC11 Antibody (4H6) is a mouse monoclonal IgG2a kappa light chain antibody that detects ABCC11 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ABCC11 antibody (4H6) is available as the non-conjugated monoclonal isotype antibody. ABCC11 is a member of the ATP-binding cassette (ABC) transporter family, which plays a crucial role in transporting various molecules across cellular membranes using energy derived from ATP hydrolysis. ABCC11 (4H6) antibody targets a protein involved in organic anion transport and influences the excretion of certain drugs and metabolites, making ABCC11 significant in pharmacogenomics and drug resistance studies. ABCC11 is primarily located in the plasma membrane of epithelial cells, particularly in tissues such as liver, kidney, and lung, where ABCC11 facilitates elimination of potentially harmful substances. Understanding ABCC11 function and localization is essential, as alterations in ABCC11 expression or activity can lead to various inherited disorders, including cystic fibrosis and neurological diseases, highlighting ABCC11′s importance in maintaining cellular homeostasis and overall health.

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ABCC11 Antibody (4H6) References:

1. The human ATP-binding cassette (ABC) transporter superfamily.  |  Dean, M., et al. 2001. Genome Res. 11: 1156-66. PMID: 11435397
2. Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12.  |  Tammur, J., et al. 2001. Gene. 273: 89-96. PMID: 11483364
3. MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer.  |  Bera, TK., et al. 2001. Mol Med. 7: 509-16. PMID: 11591886
4. Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12.  |  Yabuuchi, H., et al. 2001. Biochem Biophys Res Commun. 288: 933-9. PMID: 11688999
5. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine.  |  Guo, Y., et al. 2003. J Biol Chem. 278: 29509-14. PMID: 12764137
6. Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11).  |  Chen, ZS., et al. 2005. Mol Pharmacol. 67: 545-57. PMID: 15537867