ABCB5 Antibody (A-7): sc-515910

ABCB5 Antibody (A-7) is a mouse monoclonal IgG2b antibody that detects ABCB5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ABCB5 antibody (A-7) is available in a non-conjugated form, allowing for versatile experimental use. ABCB5, or ATP-binding cassette sub-family B member 5, is a critical multi-pass membrane protein composed of 812 amino acids, belonging to the superfamily of ATP-binding cassette transporters. ABCB5 plays a significant role in the cellular transport of various molecules, utilizing energy derived from ATP hydrolysis to facilitate movement of substances across cellular membranes. Notably, ABCB5 is implicated in the development of chemoresistance in malignant melanomas, particularly in conferring resistance to the chemotherapeutic agent doxorubicin. The presence of two isoforms, alpha and beta, resulting from alternative splicing, adds complexity to function and regulation. Understanding ABCB5′s role in drug transport and tumor growth inhibition is essential for developing targeted therapies in cancer treatment, making ABCB5 (A-7) antibody a valuable tool for researchers investigating these pathways.

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ABCB5 Antibody (A-7) References:

1. Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population.  |  Saito, S., et al. 2002. J Hum Genet. 47: 38-50. PMID: 11829140
2. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter.  |  Frank, NY., et al. 2003. J Biol Chem. 278: 47156-65. PMID: 12960149
3. Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes.  |  Chen, KG., et al. 2005. Pigment Cell Res. 18: 102-12. PMID: 15760339
4. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.  |  Frank, NY., et al. 2005. Cancer Res. 65: 4320-33. PMID: 15899824
5. Identification of cells initiating human melanomas.  |  Schatton, T., et al. 2008. Nature. 451: 345-9. PMID: 18202660
6. Learning the ABCs of melanoma-initiating cells.  |  Zabierowski, SE. and Herlyn, M. 2008. Cancer Cell. 13: 185-7. PMID: 18328422
7. Gene expression profiling of ABC transporters in dermal fibroblasts of pseudoxanthoma elasticum patients identifies new candidates involved in PXE pathogenesis.  |  Hendig, D., et al. 2008. Lab Invest. 88: 1303-15. PMID: 18936737
8. Cancer stem cells: lessons from melanoma.  |  La Porta, C. 2009. Stem Cell Rev Rep. 5: 61-5. PMID: 19093230
9. ABCB5-Targeted Chemoresistance Reversal Inhibits Merkel Cell Carcinoma Growth.  |  Kleffel, S., et al. 2016. J Invest Dermatol. 136: 838-846. PMID: 26827764
10. ABCB5-ZEB1 Axis Promotes Invasion and Metastasis in Breast Cancer Cells.  |  Yao, J., et al. 2017. Oncol Res. 25: 305-316. PMID: 28281973
11. Skin-Derived ABCB5+ Mesenchymal Stem Cells for High-Medical-Need Inflammatory Diseases: From Discovery to Entering Clinical Routine.  |  Niebergall-Roth, E., et al. 2022. Int J Mol Sci. 24: PMID: 36613507
12. Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.  |  Allikmets, R., et al. 1996. Hum Mol Genet. 5: 1649-55. PMID: 8894702

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ABCB5 Antibody (A-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ABCB5 Antibody (A-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ABCB5 Antibody (A-7) Specifications

Alternate Product Name: ABCB5

Product Clone Name: A-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids: 497-551

Epitope Target: ABCB5

Epitope Species: human

Product Reactivity/Detection: ABCB5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ABCB5 Antibody (A-7): N/A

The preferred ABCB5 antibody is ABCB5 Antibody (5H3C6): sc-517210.