ABCB5 Antibody (11A2): sc-517565
- ABCB5 Antibody (11A2) is a mouse monoclonal IgG, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant ABCB5 of human origin
- recommended for detection of ABCB5 of human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ABCB5 Antibody (11A2). This work is in progress.
ABCB5 Antibody (11A2) is a mouse monoclonal IgG antibody that detects ABCB5 in human samples through western blotting (WB). ABCB5, also known as P-glycoprotein ABCB5, is a critical member of the ATP-binding cassette (ABC) transporter family, consisting of 812 amino acids and characterized as a multi-pass membrane protein. ABCB5 plays a vital role in the transport of various molecules across cellular membranes by utilizing the energy derived from ATP hydrolysis. ABCB5 is particularly significant in malignant melanomas, contributing to resistance against the chemotherapeutic agent doxorubicin, thereby influencing treatment outcomes. Two isoforms, alpha and beta, resulting from alternative splicing, add complexity to ABCB5 function and regulation. ABCB5 not only mediates chemoresistance but also inhibits tumor growth, positioning ABCB5 as a potential target for therapeutic intervention in melanoma. Anti-ABCB5 antibody (11A2) serves as an essential tool for researchers exploring ABCB5′s role in cancer biology and drug resistance mechanisms.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ABCB5 Antibody (11A2) References:
- ABCB5 gene amplification in human leukemia cells. | Frank, NY. and Frank, MH. 2009. Leuk Res. 33: 1303-5. PMID: 19477512
- Elevated expression of ABCB5 in ocular surface squamous neoplasia. | Jongkhajornpong, P., et al. 2016. Sci Rep. 6: 20541. PMID: 26843453
- ABCB5 promotes melanoma metastasis through enhancing NF-κB p65 protein stability. | Wang, S., et al. 2017. Biochem Biophys Res Commun. 492: 18-26. PMID: 28821433
- Differential expression of ABCB5 in BRAF inhibitor-resistant melanoma cell lines. | Xiao, J., et al. 2018. BMC Cancer. 18: 675. PMID: 29929490
- ABCB5 is activated by MITF and β-catenin and is associated with melanoma differentiation. | Louphrasitthiphol, P., et al. 2020. Pigment Cell Melanoma Res. 33: 112-118. PMID: 31595650
- Genetic variation in ABCB5 associates with risk of hepatocellular carcinoma. | Leung, IC., et al. 2020. J Cell Mol Med. 24: 10705-10713. PMID: 32783366
- Islet Co-Expression of CD133 and ABCB5 in Human Retinoblastoma Specimens. | Zschoche, M., et al. 2023. Klin Monbl Augenheilkd. 240: 878-886. PMID: 34571550
- ABCB5+ mesenchymal stromal cells therapy protects from hypoxia by restoring Ca2+ homeostasis in vitro and in vivo. | Yan, K., et al. 2023. Stem Cell Res Ther. 14: 24. PMID: 36759868
- Anti-Inflammatory and Anti-(Lymph)angiogenic Properties of an ABCB5+ Limbal Mesenchymal Stem Cell Population. | Meshko, B., et al. 2024. Int J Mol Sci. 25: PMID: 39273646
- The BET inhibitor JQ1 suppresses tumor survival by ABCB5-mediated autophagy in uveal melanoma. | Liu, W., et al. 2025. Cell Signal. 125: 111483. PMID: 39442901
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ABCB5 Antibody (11A2) | sc-517565 | 100 µg/ml | $322.00 |