ABCA7 Antibody (7A1-144): sc-130576

ABCA7 Antibody (7A1-144) is a rat monoclonal IgG2a antibody that detects ABCA7 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). ABCA7 is a member of the ATP-binding cassette (ABC) transporter family, which plays a crucial role in the transport of various molecules across cellular membranes, utilizing ATP hydrolysis for energy. ABCA7 (7A1-144) antibody targets a protein particularly significant due to its involvement in lipid metabolism and homeostasis, especially in immune system cells. ABCA7 has been identified as a potential regulator of ceramide transport, which is vital for maintaining the integrity of cellular membranes and lipid composition. ABCA7 is predominantly expressed in myelolymphatic tissues, including the thymus, spleen, and bone marrow, indicating its essential role in immune function and response. Notably, ABCA7 exists in two alternatively spliced isoforms, with the full-length type I variant localized to the plasma membrane, while the type II variant is primarily found in the endoplasmic reticulum. This differential localization suggests that ABCA7 may have distinct functional roles depending on its isoform, further underscoring its importance in cellular lipid management and immune system regulation. Anti-ABCA7 antibody (7A1-144) is an invaluable tool for researchers investigating the complex mechanisms of lipid transport and metabolism in various biological contexts.

The preferred ABCA7 antibody is ABCA7 Antibody (E-11): sc-377335.