ABCA2 Antibody (9A2): sc-130575

ABCA2 Antibody (9A2) is a rat monoclonal IgG2a antibody that detects ABCA2 in mouse and rat samples through immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-ABCA2 antibody (9A2) targets the ATP-binding cassette transporter 2, a crucial protein involved in the transport of lipids and other substrates across cellular membranes, which is essential for maintaining cellular homeostasis and regulating lipid metabolism. ABCA2 is predominantly located in the endoplasmic reticulum and the plasma membrane, where ABCA2 plays a significant role in lipid transport and membrane trafficking. ABCA2 function is vital for processes such as cholesterol import, as ABCA2 mRNA expression increases in human macrophages during cholesterol uptake, highlighting ABCA2′s importance in lipid metabolism and cellular differentiation. Furthermore, the gene encoding ABCA2 consists of 48 exons within a compact 21 kb genomic region, and ABCA2′s promoter contains binding sites for transcription factors that are critical for the differentiation of myeloid and neural cells, suggesting ABCA2 may also influence neural development. ABCA2 monoclonal antibody (9A2) effectively detects ABCA2, making this reagent an invaluable tool for researchers studying lipid metabolism and related cellular processes.