Date published: 2026-4-30

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Abafungin (CAS 129639-79-8)

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Application:
Abafungin is a broad-spectrum antifungal agent
CAS Number:
129639-79-8
Purity:
≥95%
Molecular Weight:
378.49
Molecular Formula:
C21H22N4OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Abafungin is a chemical that functions as an antifungal agent. It inhibits the growth of fungi by disrupting the synthesis of their cell walls. This disruption occurs through the inhibition of the enzyme 1,3-beta-D-glucan synthase, which is responsible for the production of beta-glucan, a key component of fungal cell walls. By targeting this specific enzyme, abafungin interferes with the structural integrity of fungal cells, ultimately leading to their death. Abafungin enables the study of fungal cell wall synthesis and for investigating potential strategies for controlling fungal infections. Its ability to target fungal cell wall synthesis without affecting mammalian cells may be a useful compound for experiments.


Abafungin (CAS 129639-79-8) References

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  3. Shape and pharmacophore-based virtual screening to identify potential cytochrome P450 sterol 14α-demethylase inhibitors.  |  Reddy, KK., et al. 2013. J Recept Signal Transduct Res. 33: 234-43. PMID: 23638723
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  7. Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans.  |  Ishita, K., et al. 2018. Bioorg Med Chem. 26: 2251-2261. PMID: 29580849
  8. Stereoselective synthesis, X-ray analysis, computational studies and biological evaluation of new thiazole derivatives as potential anticancer agents.  |  Mabkhot, YN., et al. 2018. Chem Cent J. 12: 56. PMID: 29748782
  9. Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity.  |  Chen, JP., et al. 2021. Eur J Med Chem. 217: 113340. PMID: 33725630
  10. Erg6p is essential for antifungal drug resistance, plasma membrane properties and cell wall integrity in Candida glabrata.  |  Elias, D., et al. 2022. FEMS Yeast Res. 21: PMID: 36047961
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Abafungin, 100 mg

sc-474844
100 mg
$199.00