Abacavir hydrochloride CAS: 136470-78-5 (non-salt)
MF: C14H18N6O•HCl
MW: 322.80
A nucleoside reverse transcriptase inhibitor (NRTI).

Abacavir hydrochloride (CAS 136470-78-5 (non-salt))

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Application: Abacavir hydrochloride is a nucleoside reverse transcriptase inhibitor (NRTI)
CAS Number: 136470-78-5 (non-salt)
Purity: ≥98%
Molecular Weight: 322.80
Molecular Formula: C14H18N6O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Abacavir hydrochloride is the hydrochloride form of Abacavir [also called Ziagen (sc-338739)], a nucleoside reverse transcriptase inhibitor (NRTI). NRTIs work by blocking HIV reverse transcriptase, an HIV enzyme. Abacavir hydrochloride is an inhibitor of HIV-1 RT.


References

1. Hoetelmans, R.M. et al. 1997. Pharm World Sci. 19(4): 159-175. PMID: 9297727

2. Beach, J.W. 1998. Clin Ther. 20(1): 2-25; discussion l. PMID: 9522101

3. McDowell, J.A. et al. 1999. Antimicrob. Agents Chemother. 43(12): 2855-2861. PMID: 10582871

Physical State :
Solid
Solubility :
Soluble in PBS(PH=7.2) (~1 mg/ml), and DMSO (~0.15 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D 1.86
IC50 :
Bone marrow progenitor cells: IC50 = 110 µM (human); HIV1 reverse transcriptase p66/p51: IC50 = 130 nM; Immunodeficiency virus 1: IC50 = 910 nM (human); Immunodeficiency virus 1: EC5050 = 1900 nM (human)
Ki Data :
HIV reverse transcriptase: Ki= 21 nM
pK Values :
pKb: 4.86 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
19767005
MDL Number :
MFCD18427212
SMILES :
C1CC1NC2=NC(=NC3=C2N=CN3C4CC(C=C4)CO)N.Cl

Download SDS (MSDS)

Certificate of Analysis

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Abacavir hydrochloride (CAS 136470-78-5 (non-salt))  Product Citations

See how others have used Abacavir hydrochloride (CAS 136470-78-5 (non-salt)). Click on the entry to view the PubMed entry .

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PMID: # 24487230  Thein, P. et al. 2014. Hear. Res. 310: 27-35.

Citations 1 to 1 of 1 total
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