AATK Antibody (L-37): sc-100436

AATK Antibody (L-37) is a mouse monoclonal IgG1 kappa light chain antibody that detects AATK protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-AATK antibody (L-37) is available as the non-conjugated form. AATK, or Apoptosis-associated tyrosine kinase, also known as LMR1 (Lemur tyrosine kinase 1), AATYK, AATYK1, or LMTK1, is a single-pass type I membrane protein primarily localized in the brain, where AATK plays a critical role in neuronal differentiation and apoptosis. AATK′s importance lies in its function within death activation pathways, which are essential for regulating neuronal apoptosis—a process that minimizes brain damage and ensures proper neural development. AATK expression is induced during apoptosis, suggesting involvement in growth arrest of myeloid precursor cells. Structurally, AATK features a proline-rich domain at its C-terminus and a tyrosine kinase domain at its N-terminus, which contribute to in vitro kinase activity. Notably, three isoforms of AATK exist due to alternative splicing events, allowing for functional diversity in cellular processes.

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AATK Antibody (L-37) References:

1. Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization.  |  Seki, N., et al. 1999. J Hum Genet. 44: 141-2. PMID: 10083745
2. A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line.  |  Raghunath, M., et al. 2000. Brain Res Mol Brain Res. 77: 151-62. PMID: 10837911
3. Characterization of an alternatively spliced AATYK mRNA: expression pattern of AATYK in the brain and neuronal cells.  |  Baker, SJ., et al. 2001. Oncogene. 20: 1015-21. PMID: 11314039
4. Characterization of the apoptosis-associated tyrosine kinase (AATYK) expressed in the CNS.  |  Tomomura, M., et al. 2001. Oncogene. 20: 1022-32. PMID: 11314040
5. Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain.  |  Tomomura, M., et al. 2003. Brain Res Mol Brain Res. 112: 103-12. PMID: 12670708
6. Apoptosis-associated tyrosine kinase (AATYK) has differential Ca2+-dependent phosphorylation states in response to survival and apoptotic conditions in cerebellar granule cells.  |  Tomomura, M. and Furuichi, T. 2005. J Biol Chem. 280: 35157-63. PMID: 16100393
7. miR-1250-5p is a novel tumor suppressive intronic miRNA hypermethylated in non-Hodgkin's lymphoma: novel targets with impact on ERK signaling and cell migration.  |  Zhang, MY., et al. 2021. Cell Commun Signal. 19: 62. PMID: 34044822
8. CircPTK2 Suppresses the Progression of Gastric Cancer by Targeting the MiR-196a-3p/AATK Axis.  |  Gao, L., et al. 2021. Front Oncol. 11: 706415. PMID: 34604044
9. Epigenetically silenced apoptosis-associated tyrosine kinase (AATK) facilitates a decreased expression of Cyclin D1 and WEE1, phosphorylates TP53 and reduces cell proliferation in a kinase-dependent manner.  |  Woods, ML., et al. 2022. Cancer Gene Ther. 29: 1975-1987. PMID: 35902728
10. The diagnostic yield, candidate genes, and pitfalls for a genetic study of intellectual disability in 118 middle eastern families.  |  Al-Kasbi, G., et al. 2022. Sci Rep. 12: 18862. PMID: 36344539
11. Glycolytic metabolite phosphoenolpyruvate protects host from viral infection through promoting AATK expression.  |  Zhao, L., et al. 2023. Eur J Immunol. 53: e2350536. PMID: 37724936
12. Downregulation of AATK enhances susceptibility to ferroptosis by promoting endosome recycling in gefitinib-resistant lung cancer cells.  |  Lee, WC., et al. 2025. J Pathol.. PMID: 39871626

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AATK Antibody (L-37) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-AATK Antibody (L-37) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AATK Antibody (L-37) Specifications

Alternate Product Name: AATK

Product Clone Name: L-37

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 161-260

Epitope Target: AATK

Epitope Species: human

Product Reactivity/Detection: AATK

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for AATK Antibody (L-37): N/A