Molecular structure of AAMU, CAS Number: 19893-78-8
AAMU (CAS 19893-78-8)
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Alternate Names:
5-Acetylamino-6-amino-3-methyluracil; N-(4-Amino-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)acetimide
Application:
AAMU is CYP1A2 metabolite of caffeine
CAS Number:
19893-78-8
Molecular Weight:
198.18
Molecular Formula:
C7H10N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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AAMU is a CYP1A2 metabolite of caffeine used as a building block for the synthesis of biologically active molecules. It has also been used in the development of molecular probes for the analysis of protein-nucleic acid interactions. AAMU can interact with DNA, RNA, proteins, and other molecules. This allows it to regulate gene expression, as well as cell proliferation, differentiation, and apoptosis.
AAMU (CAS 19893-78-8) References
- Validity of an ELISA for N-acetyltransferase-2 (NAT2) phenotyping. | Wong, P., et al. 2001. J Immunol Methods. 251: 1-9. PMID: 11292476
- Extractionless method for the simultaneous high-performance liquid chromatographic determination of urinary caffeine metabolites for N-acetyltransferase 2, cytochrome P450 1A2 and xanthine oxidase activity assessment. | Nyéki, A., et al. 2001. J Chromatogr B Biomed Sci Appl. 755: 73-84. PMID: 11393735
- The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activities in humans. | Tsutsumi, K., et al. 2001. Clin Pharmacol Ther. 70: 121-5. PMID: 11503005
- Stability of 5-acetamido-6-formylamino-3-methyluracil in buffers and urine. | Wong, P., et al. 2002. J Pharm Biomed Anal. 28: 693-700. PMID: 12008149
- NAT2 and CYP1A2 phenotyping with caffeine: head-to-head comparison of AFMU vs. AAMU in the urine metabolite ratios. | Nyéki, A., et al. 2003. Br J Clin Pharmacol. 55: 62-7. PMID: 12534641
- Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure. | Jetter, A., et al. 2004. Eur J Clin Pharmacol. 60: 17-21. PMID: 14747882
- Measurement of caffeine and five of the major metabolites in urine by high-performance liquid chromatography/tandem mass spectrometry. | Weimann, A., et al. 2005. J Mass Spectrom. 40: 307-16. PMID: 15685651
- Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans. | Kimura, M., et al. 2005. Drug Metab Dispos. 33: 1361-6. PMID: 15980104
- Phenotype-genotype analysis of CYP1A2 in Japanese patients receiving oral theophylline therapy. | Takata, K., et al. 2006. Eur J Clin Pharmacol. 62: 23-8. PMID: 16385402
- Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected? | Jetter, A., et al. 2009. Eur J Clin Pharmacol. 65: 411-7. PMID: 19082994
- Caffeine as a metabolic probe: validation of its use for acetylator phenotyping. | Tang, BK., et al. 1991. Clin Pharmacol Ther. 49: 648-57. PMID: 2060254
- N-acetylator variability in Down's syndrome: characterization with caffeine. | Morris, ME., et al. 1989. Clin Pharmacol Ther. 46: 359-66. PMID: 2528436
- A competitive enzyme linked immunosorbent assay for the determination of N-acetyltransferase (NAT2) phenotypes. | Wong, P., et al. 1995. J Pharm Biomed Anal. 13: 1079-86. PMID: 8573631
- CYP1A2 activity, gender and smoking, as variables influencing the toxicity of caffeine. | Carrillo, JA. and Benitez, J. 1996. Br J Clin Pharmacol. 41: 605-8. PMID: 8799528
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AAMU, 10 mg | sc-217117 | 10 mg | $326.00 |