AAF-CMK is a serine protease inhibitor which irreversibly inhibits TPPII (tripeptidyl peptidase II), a giant protease which may substitute for some proteasome functions1, and reversibly inhibits Cln2 (TPPI). AAF-CMK shows only marginal inhibition of the chymotrypsin-like activity of the proteasome.
1. Vines, D., 1998. Purification and characterisation of a tripeptidyl aminopeptidase I from rat spleen. Biochimica et biophysica acta. 1384(2): 233-42. PMID: 9659384 2. Geier, E., 1999. A giant protease with potential to substitute for some functions of the proteasome. Science (New York, N.Y.). 283(5404): 978-81. PMID: 9974389
Soluble in water.
Store at -20° C
tripeptidyl peptidase I: Ki= 63 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
ZhouZhou, Y. et al. (PubMed 23818952) used the tripeptidyl peptidase II (TPPII) inhibitor AAF-CMK to demonstrate that TPPII regulates sperm function by modulating intracellular Ca(2+) stores via the ryanodine receptor. -SCBT Publication Review
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