AAF-CMK CAS: 184901-82-4
MF: C16H22ClN3O3•C2HF3O2
MW: 453.9
A serine protease inhibitor that inhibits tripeptidyl peptidase II (TPPII).

AAF-CMK (CAS 184901-82-4)

AAF-CMK | CAS 184901-82-4 is rated 5.0 out of 5 by 1.
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Alternate Names: Tripeptidyl Peptidase Inhibitor
Application: AAF-CMK is a serine protease inhibitor that inhibits tripeptidyl peptidase II (TPPII)
CAS Number: 184901-82-4
Purity: ≥95%
Molecular Weight: 453.9
Molecular Formula: C16H22ClN3O3•C2HF3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

AAF-CMK is a serine protease inhibitor which irreversibly inhibits TPPII (tripeptidyl peptidase II), a giant protease which may substitute for some proteasome functions1, and reversibly inhibits Cln2 (TPPI). AAF-CMK shows only marginal inhibition of the chymotrypsin-like activity of the proteasome.


References

1. Vines, D., 1998. Purification and characterisation of a tripeptidyl aminopeptidase I from rat spleen. Biochimica et biophysica acta. 1384(2): 233-42. PMID: 9659384
2. Geier, E., 1999. A giant protease with potential to substitute for some functions of the proteasome. Science (New York, N.Y.). 283(5404): 978-81. PMID: 9974389

Physical State :
Solid
Sequence :
Ala-Ala-Phe-CMK
Solubility :
Soluble in water.
Storage :
Store at -20° C
Ki Data :
tripeptidyl peptidase I: Ki= 63 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C[[email protected]@H](C(=O)NC(=O)[[email protected]](C)N[[email protected]@H](CC1=CC=CC=C1)C(=O)CCl)N.C(=O)(C(F)(F)F)O

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Certificate of Analysis

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AAF-CMK (CAS 184901-82-4)  Product Citations

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Citations 1 to 1 of 1 total

PMID: # 21342435  Dabrazhynetskaya, A. et al. 2011. J Cell Mol Med. 16: -.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Zhou Zhou, Y. et al. (PubMed 23818952) used the tripeptidyl peptidase II (TPPII) inhibitor AAF-CMK to demonstrate that TPPII regulates sperm function by modulating intracellular Ca(2+) stores via the ryanodine receptor. -SCBT Publication Review
Date published: 2015-06-29
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