Date published: 2026-5-17

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AA 29504 (CAS 945828-50-2)

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Alternate Names:
N1-Ethoxycarbonyl-N4-[(2,4,6-trimethylpheny)lmethyl]-1,2,4-triaminobenzene
Application:
AA 29504 is a positive allosteric modulator of GABAA receptors
CAS Number:
945828-50-2
Molecular Weight:
327.42
Molecular Formula:
C19H25N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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AA 29504 is notable for its activity as a positive allosteric modulator of GABAA receptors. This compound is the subject of neuroscience and biochemical research, where it is employed to study the modulation of this receptor subtype, which plays a critical role in mediating inhibitory neurotransmission in the central nervous system. Its modulatory effects on GABAA receptors are of particular interest for understanding the complex mechanisms underlying synaptic plasticity and network oscillations. By binding to a site distinct from the neurotransmitter′s binding site, AA 29504 is able to enhance the receptor′s response to GABA, providing insights into the conformational changes associated with receptor activation. Furthermore, AA 29504 aids in dissecting the physiological and pathological roles of GABAA receptors in various neural processes.


AA 29504 (CAS 945828-50-2) References

  1. Pharmacological characterization of a novel positive modulator at alpha 4 beta 3 delta-containing extrasynaptic GABA(A) receptors.  |  Hoestgaard-Jensen, K., et al. 2010. Neuropharmacology. 58: 702-11. PMID: 20060846
  2. Extrasynaptic GABAA receptor activation reverses recognition memory deficits in an animal model of schizophrenia.  |  Damgaard, T., et al. 2011. Psychopharmacology (Berl). 214: 403-13. PMID: 20957350
  3. A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors.  |  Jensen, ML., et al. 2013. Br J Pharmacol. 168: 1118-32. PMID: 23061935
  4. Menthol enhances phasic and tonic GABAA receptor-mediated currents in midbrain periaqueductal grey neurons.  |  Lau, BK., et al. 2014. Br J Pharmacol. 171: 2803-13. PMID: 24460753
  5. The anticonvulsant retigabine is a subtype selective modulator of GABAA receptors.  |  Treven, M., et al. 2015. Epilepsia. 56: 647-57. PMID: 25779225
  6. Monastrol, a 3,4-dihydropyrimidin-2(1H)-thione, as structural scaffold for the development of modulators for GHB high-affinity binding sites and α1β2Δ GABAA receptors.  |  Damgaard, M., et al. 2017. Eur J Med Chem. 138: 300-312. PMID: 28683403
  7. Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors.  |  Olander, ER., et al. 2018. Biochem Pharmacol. 150: 305-319. PMID: 29454619
  8. Effects of Statin Therapy on the Risk of Intracerebral Hemorrhage in Korean Patients with Hyperlipidemia.  |  Jung, M. and Lee, S. 2019. Pharmacotherapy. 39: 129-139. PMID: 30585646
  9. The effects of a competitive antagonist on GABA-evoked currents in the presence of sedative-hypnotic agents.  |  McGrath, M., et al. 2020. Pharmacol Rep. 72: 260-266. PMID: 32016849
  10. Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor.  |  Belelli, D., et al. 2020. Neurobiol Stress. 12: 100207. PMID: 32435660
  11. Alcohol-Responsive Hyperkinetic Movement Disorders-a Mechanistic Hypothesis.  |  Frucht, SJ. and Riboldi, GM. 2020. Tremor Other Hyperkinet Mov (N Y). 10: 47. PMID: 33178485
  12. Molecular Determinants Underlying Delta Selective Compound 2 Activity at Δ-Containing GABAA Receptors.  |  Falk-Petersen, CB., et al. 2021. Mol Pharmacol. 100: 46-56. PMID: 33990405
  13. Delta-containing GABAA receptors in pain management: Promising targets for novel analgesics.  |  Luo, Y., et al. 2021. Neuropharmacology. 195: 108675. PMID: 34153311
  14. The Influence of AA29504 on GABAA Receptor Ligand Binding Properties and Its Implications on Subtype Selectivity.  |  Sikstus, S., et al. 2022. Neurochem Res. 47: 667-678. PMID: 34727270

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

AA 29504, 5 mg

sc-361096
5 mg
$87.00

AA 29504, 25 mg

sc-361096A
25 mg
$364.00