Molecular structure of A66, CAS Number: 1166227-08-2
A66 (CAS 1166227-08-2)
Application:
A66 is an inhibitor for oncogenic forms of p110
CAS Number:
1166227-08-2
Purity:
≥98%
Molecular Weight:
393.5
Molecular Formula:
C17H23N5O2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A66 inhibits the oncogenic forms of p110α such as E545K H1047R with IC50 of 30 nM and 43 nM, respectively. A66 displays >100-fold selectivity for p110α over other class-I PI3K isoforms. Among the class-II PI3Ks, class-III PI3Ks, and PI4Ks, A66 only exhibits limited cross-reactivity with the class-II PI3K PI3K-C2β and the PI4Kβ isoform of PI4K with IC50 of 462 nM and 236 nM, respectively. A66 exhibits no inhibitory activity against other lipid kinases or the related kinases DNA-PK and mTOR. A66 treatment at 0.7 μM induces a 75-80% reduction in focus formation by the highly transforming p85α iSH2 mutants KS459delN, DKRMN-S560del, and K379E, and reduces the phosphorylation of Akt on T308 by all p85 mutants.
Inhibitor of:
Bpifa6, Clm3, CREB Binding Protein (CBP), DYNC2LI1, HNF-4γ, NOMO3, PhLP, PI 3-kinase p110 alpha, PIPK I γ, PIPK II α, Plk, SEMA4C, Six6os1, TTF2, and YadA.Activator of:
AQR, FKHRL1, Gab 2, GKLF, IRS-4, PDK1, Smurf2, and SSBP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A66, 5 mg | sc-364394 | 5 mg | $255.00 | |||
A66, 50 mg | sc-364394A | 50 mg | $1455.00 |