Date published: 2026-6-6

1-800-457-3801

SCBT Portrait Logo
Seach Input

A54556A (CAS 95398-45-1)

0.0(0)
Write a reviewAsk a question

Application:
A54556A is a potent antibiotic that is active against Gram positive and Gram negative bacteria
CAS Number:
95398-45-1
Purity:
≥95%
Molecular Weight:
718.84
Molecular Formula:
C38H50N6O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

A54556A is a chemical that functions as an inhibitor of protein synthesis. It acts by binding to the 50S ribosomal subunit. This binding prevents the formation of peptide bonds between amino acids, ultimately halting the elongation of the polypeptide chain during translation. As a result, A54556A disrupts the process of protein synthesis, leading to the inhibition of bacterial growth. Its mechanism of action at the molecular level involves interfering with the ribosome′s ability to catalyze the formation of peptide bonds, thereby disrupting the production necessary proteins for bacterial survival. A54556A′s function as a protein synthesis inhibitor may be useful in studying the molecular mechanisms of translation and for exploring potential targets for antibacterial agents.


A54556A (CAS 95398-45-1) References

  1. Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics.  |  Hinzen, B., et al. 2006. ChemMedChem. 1: 689-93. PMID: 16902918
  2. Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics.  |  Obrecht, D., et al. 2009. Curr Med Chem. 16: 42-65. PMID: 19149562
  3. Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism.  |  Lee, BG., et al. 2010. Nat Struct Mol Biol. 17: 471-8. PMID: 20305655
  4. Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ.  |  Sass, P., et al. 2011. Proc Natl Acad Sci U S A. 108: 17474-9. PMID: 21969594
  5. Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity.  |  Carney, DW., et al. 2014. J Am Chem Soc. 136: 1922-9. PMID: 24422534
  6. Acyldepsipeptide antibiotics as a potential therapeutic agent against Clostridium difficile recurrent infections.  |  Gil, F. and Paredes-Sabja, D. 2016. Future Microbiol. 11: 1179-89. PMID: 27546386
  7. The development of small-molecule modulators for ClpP protease activity.  |  Ye, F., et al. 2016. Mol Biosyst. 13: 23-31. PMID: 27831584
  8. Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice.  |  Choi, SE., et al. 2022. J Hepatol. 77: 735-747. PMID: 35421426
  9. Antibacterial Activity and Cytotoxicity Screening of Acyldepsipeptide-1 Analogues Conjugated to Silver/Indium/Sulphide Quantum Dots.  |  Cobongela, SZZ., et al. 2024. Antibiotics (Basel). 13: PMID: 38391569

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

A54556A, 1 mg

sc-397312
1 mg
$311.00

A54556A, 50 mg

sc-397312A
50 mg
$7080.00

A54556A, 100 mg

sc-397312B
100 mg
$13530.00