Date published: 2025-11-1

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A23187 (Mixed Calcium-Magnesium Salt) (CAS 52665-69-7)

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Alternate Names:
Calcimycin
Application:
A23187 (Mixed Calcium-Magnesium Salt) is a compound used in cell activation
CAS Number:
52665-69-7
Purity:
≥98%
Molecular Weight:
523.62
Molecular Formula:
C29H37N3O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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A23187 (Mixed Calcium-Magnesium Salt) is a compound known as an ionophore, which has the ability to transport calcium and magnesium ions across biological membranes. In research applications, A23187 (Mixed Calcium-Magnesium Salt) is widely used to study the role of calcium in cellular processes by artificially increasing the intracellular calcium concentration in a controlled manner. It is particularly useful in experiments investigating calcium-dependent cellular signaling pathways, such as muscle contraction, neurotransmitter release, and activation of calcium-dependent enzymes. Additionally, A23187 (Mixed Calcium-Magnesium Salt) is used in immunology research to induce the activation of T-cells and other immune cells by mimicking calcium-mediated signaling events. In the field of cell biology, researchers utilize this ionophore to understand the impact of altered calcium levels on cell proliferation, apoptosis, and other vital cellular functions.


A23187 (Mixed Calcium-Magnesium Salt) (CAS 52665-69-7) References

  1. Release of non-mast cell histamine from rat aorta.  |  Gruetter, CA., et al. 2002. Life Sci. 70: 1709-17. PMID: 11991258
  2. Altered T-cell responses by the periodontal pathogen Porphyromonas gingivalis.  |  Khalaf, H. and Bengtsson, T. 2012. PLoS One. 7: e45192. PMID: 22984628
  3. Suppression of inflammatory gene expression in T cells by Porphyromonas gingivalis is mediated by targeting MAPK signaling.  |  Khalaf, H., et al. 2013. Cell Mol Immunol. 10: 413-22. PMID: 23892429
  4. Endothelium-dependent modulation of angiotensin II-induced contraction in blood vessels.  |  Gruetter, CA., et al. 1988. Eur J Pharmacol. 146: 85-95. PMID: 2832199
  5. Bradykinin-induced endothelium-dependent relaxation of bovine intrapulmonary artery and vein.  |  Gruetter, CA. and Lemke, SM. 1986. Eur J Pharmacol. 122: 363-7. PMID: 3011448
  6. Single-Cell Analysis of Cytokine mRNA and Protein Expression by Flow Cytometry.  |  Pal, R., et al. 2020. Curr Protoc Cytom. 92: e69. PMID: 32092227
  7. The anti-allergic potential of stingless bee honey from different botanical sources via modulation of mast cell degranulation.  |  Yong, PYA., et al. 2023. BMC Complement Med Ther. 23: 307. PMID: 37667314
  8. Effects of activation with a Ca ionophore and roscovitine on the development of human oocytes that failed to fertilize after ICSI.  |  Suto, A., et al. 2023. J Med Invest. 70: 321-324. PMID: 37940514

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

A23187 (Mixed Calcium-Magnesium Salt), 5 mg

sc-221193
5 mg
$92.00

A23187 (Mixed Calcium-Magnesium Salt), 10 mg

sc-221193A
10 mg
$163.00