Molecular structure of A-85380 dihydrochloride
A-85380 dihydrochloride
Molecular Weight:
237.13
Molecular Formula:
C9H14Cl2N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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A potent and selective neuronal nicotinic acetylcholine receptor (nAChR) agonist. The 5-125I-analog has been used as a selective radioligand for the α42 nAChR subtype. Fluorinated analogs have been used for PET imaging of nAChRs.
A-85380 dihydrochloride References
- 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. | Mukhin, AG., et al. 2000. Mol Pharmacol. 57: 642-9. PMID: 10692507
- Spinal mechanisms underlying A-85380-induced effects on acute thermal pain. | Rueter, LE., et al. 2000. Brain Res. 872: 93-101. PMID: 10924680
- A-85380 and epibatidine each interact with disparate spinal nicotinic receptor subtypes to achieve analgesia and nociception. | Khan, IM., et al. 2001. J Pharmacol Exp Ther. 297: 230-9. PMID: 11259549
- Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic pain. | Rueter, LE., et al. 2003. Pain. 103: 269-276. PMID: 12791433
- Mechanism of action of A-85380 in an animal model of depression. | Buckley, MJ., et al. 2004. Prog Neuropsychopharmacol Biol Psychiatry. 28: 723-30. PMID: 15276699
- A-85380: a pharmacological probe for the preclinical and clinical investigation of the alphabeta neuronal nicotinic acetylcholine receptor. | Rueter, LE., et al. 2006. CNS Drug Rev. 12: 100-12. PMID: 16958984
- Synthesis and biological evaluation of Tc-99m-cyclopentadienyltricarbonyl-technetium-labeled A-85380: An imaging probe for single-photon emission computed tomography investigation of nicotinic acetylcholine receptors in the brain. | Kimura, H., et al. 2019. Bioorg Med Chem. 27: 2245-2252. PMID: 31047775
- Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. | Abreo, MA., et al. 1996. J Med Chem. 39: 817-25. PMID: 8632405
- A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand. | Sullivan, JP., et al. 1996. Neuropharmacology. 35: 725-34. PMID: 8887981
- 2-[18F]Fluoro-A-85380, an in vivo tracer for the nicotinic acetylcholine receptors. | Horti, AG., et al. 1998. Nucl Med Biol. 25: 599-603. PMID: 9804040
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A-85380 dihydrochloride, 5 mg | sc-300146 | 5 mg | $849.00 |