Molecular structure of A 77636 hydrochloride, CAS Number: 145307-34-2
A 77636 hydrochloride (CAS 145307-34-2)
See product citations (3)
Application:
A 77636 hydrochloride is a selective dopamine D1-like receptor agonist
CAS Number:
145307-34-2
Purity:
>98%
Molecular Weight:
365.9
Molecular Formula:
C20H27NO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A 77636 hydrochloride is a selective and potent dopamine D1-like agonist stimulating the release of adenylate cyclase. It has been reported that upon binding to D1DR (dopamine D1 receptors), A 77636 hydrochloride displays 85% of the intrinsic activity that dopamine provides. Some studies show that A 77636 hydrochloride also increases the release of cortical acetylcholine. A 77636 hydrochloride is an activator of D1DR.
A 77636 hydrochloride (CAS 145307-34-2) References
- A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. | Kebabian, JW., et al. 1992. Eur J Pharmacol. 229: 203-9. PMID: 1362704
- Negative feedback regulation of nigrostriatal dopamine release: mediation by striatal D1 receptors. | Saklayen, SS., et al. 2004. J Pharmacol Exp Ther. 311: 342-8. PMID: 15175419
- Effects of the intravitreal administration of dopaminergic ligands on the b-wave amplitude of the rabbit electroretinogram. | Huppé-Gourgues, F., et al. 2005. Vision Res. 45: 137-45. PMID: 15581915
- Development and validation of a higher throughput screening approach to genotoxicity testing using the GADD45a-GFP GreenScreen HC assay. | Knight, AW., et al. 2009. J Biomol Screen. 14: 16-30. PMID: 19171918
- Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. | Jones, DC., et al. 2010. Biochem Pharmacol. 80: 1478-86. PMID: 20696141
- Validating a firefly luciferase-based high-throughput screening assay for antimalarial drug discovery. | Che, P., et al. 2012. Assay Drug Dev Technol. 10: 61-8. PMID: 22050430
- Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection. | Kota, KP., et al. 2013. PLoS One. 8: e55167. PMID: 23383093
- A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. | Yang, YM., et al. 2013. Cell Stem Cell. 12: 713-26. PMID: 23602540
- Dopamine D4 receptor antagonist inhibits melanogenesis through transcriptional downregulation of MITF via ERK signalling. | Jung, JM., et al. 2016. Exp Dermatol. 25: 325-8. PMID: 26782007
- Characterization of Influenza Virus Pseudotyped with Ebolavirus Glycoprotein. | Xiao, JH., et al. 2018. J Virol. 92: PMID: 29212933
- The potent and selective dopamine D1 receptor agonist A-77636 increases cortical and hippocampal acetylcholine release in the rat. | Acquas, E., et al. 1994. Eur J Pharmacol. 260: 85-7. PMID: 7957630
- Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency. | Lewis, MM., et al. 1998. J Pharmacol Exp Ther. 286: 345-53. PMID: 9655879
Activator of:
D1DR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A 77636 hydrochloride, 10 mg | sc-203486 | 10 mg | $203.00 | |||
A 77636 hydrochloride, 50 mg | sc-203486A | 50 mg | $842.00 |