Date published: 2025-12-5

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A 68930 hydrochloride (CAS 130465-39-3)

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Alternate Names:
cis-(±)-1-(Aminomethyl)-3,4-dihydro-3-phenyl-1H-2-benzopyran-5,6-diol hydrochloride
Application:
A 68930 hydrochloride is A potent and selective D1-like dopamine receptor agonist
CAS Number:
130465-39-3
Purity:
≥98%
Molecular Weight:
307.77
Molecular Formula:
C16H17NO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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A 68930 hydrochloride is a compound of interest in the field of neuroscience research, particularly for its role as a dopaminergic agonist. It selectively targets dopamine D1 receptors, which are involved in the modulation of numerous neurological processes. Studies involving A 68930 hydrochloride focus on understanding the signaling pathways and neuronal circuits influenced by dopamine D1 receptors. Research applications often include the use of this compound to investigate the physiological consequences of D1 receptor activation in the central nervous system. A 68930 hydrochloride is also used to model the effects of dopaminergic stimulation in experimental applications, which can elucidate the molecular and cellular underpinnings of behaviors and responses associated with dopamine. Furthermore, its hydrochloride form enhances its solubility in aqueous solutions, making it more suitable for in vitro experiments.


A 68930 hydrochloride (CAS 130465-39-3) References

  1. Comparison of the D1-dopamine agonists SKF-38393 and A-68930 in neonatal 6-hydroxydopamine-lesioned rats: behavioral effects and induction of c-fos-like immunoreactivity.  |  Johnson, KB., et al. 1992. J Pharmacol Exp Ther. 262: 855-65. PMID: 1354257
  2. The anorectic effect of the selective dopamine D1-receptor agonist A-77636 determined by meal pattern analysis in free-feeding rats.  |  Cooper, SJ., et al. 2006. Eur J Pharmacol. 532: 253-7. PMID: 16478622
  3. D1 receptor antagonist-induced long-term depression in the medial prefrontal cortex of rat, in vivo: an animal model of psychiatric hypofrontality.  |  Coppa-Hopman, R., et al. 2009. J Psychopharmacol. 23: 672-85. PMID: 18635697
  4. Comparison of the effects of central and peripheral dopamine receptor activation on evoked firing in the trigeminocervical complex.  |  Charbit, AR., et al. 2009. J Pharmacol Exp Ther. 331: 752-63. PMID: 19657051
  5. (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist.  |  DeNinno, MP., et al. 1990. J Med Chem. 33: 2948-50. PMID: 1977907
  6. Comparison of SHR, WKY and Wistar rats in different behavioural animal models: effect of dopamine D1 and alpha2 agonists.  |  Langen, B. and Dost, R. 2011. Atten Defic Hyperact Disord. 3: 1-12. PMID: 21432613
  7. A68930: a potent and specific agonist for the D-1 dopamine receptor.  |  Kebabian, JW., et al. 1990. Am J Hypertens. 3: 40S-42S. PMID: 2143387
  8. Effect of PDE10A inhibitors on MK-801-induced immobility in the forced swim test.  |  Langen, B., et al. 2012. Psychopharmacology (Berl). 221: 249-59. PMID: 22147257
  9. C-terminal di-leucine motif of dopamine D₁ receptor plays an important role in its plasma membrane trafficking.  |  Guo, Y. and Jose, PA. 2011. PLoS One. 6: e29204. PMID: 22206002
  10. Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice.  |  Yamamura, Y., et al. 2013. Front Cell Neurosci. 7: 12. PMID: 23420105
  11. The dopaminergic stabilizer pridopidine increases neuronal activity of pyramidal neurons in the prefrontal cortex.  |  Gronier, B., et al. 2013. J Neural Transm (Vienna). 120: 1281-94. PMID: 23468085
  12. A novel tyrosine kinase inhibitor AMN107 (nilotinib) normalizes striatal motor behaviors in a mouse model of Parkinson's disease.  |  Tanabe, A., et al. 2014. Front Cell Neurosci. 8: 50. PMID: 24600352
  13. Psychopharmacological distinction between novel full-efficacy 'D1-like' dopamine receptor agonists.  |  Deveney, AM. and Waddington, JL. 1997. Pharmacol Biochem Behav. 58: 551-8. PMID: 9300618

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

A 68930 hydrochloride, 10 mg

sc-203485
10 mg
$173.00

A 68930 hydrochloride, 50 mg

sc-203485A
50 mg
$719.00