Molecular structure of A 582941, CAS Number: 848591-90-2
A 582941 (CAS 848591-90-2)
See product citations (2)
Application:
A 582941 is a selective AChR α7 partial agonist
CAS Number:
848591-90-2
Purity:
>98%
Molecular Weight:
280.37
Molecular Formula:
C17H20N4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
A 582941, also known as A-582941 free base, is an organic compound that serves as a valuable building block for creating various active ingredients. This compound, known for its high solubility and non-toxic nature, possesses minimal potential for causing harm. Extensively utilized in numerous research studies, A 582941 exhibits a diverse array of biological and physiological effects. Within the realm of scientific research, A 582941 has found widespread application in both in vivo and in vitro investigations. It is believed to function as an agonist for specific receptors in the body, such as the 5-HT2A receptor. This receptor plays a role in the regulation of serotonin.
A 582941 (CAS 848591-90-2) References
- Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys. | Buccafusco, JJ., et al. 2007. Biochem Pharmacol. 74: 1202-11. PMID: 17706609
- Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways. | Bitner, RS., et al. 2007. J Neurosci. 27: 10578-87. PMID: 17898229
- Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties. | Tietje, KR., et al. 2008. CNS Neurosci Ther. 14: 65-82. PMID: 18482100
- The selective alpha7 nicotinic acetylcholine receptor agonist A-582941 activates immediate early genes in limbic regions of the forebrain: Differential effects in the juvenile and adult rat. | Thomsen, MS., et al. 2008. Neuroscience. 154: 741-53. PMID: 18495359
- Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo. | Bitner, RS., et al. 2009. Brain Res. 1265: 65-74. PMID: 19230830
- Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors. | Briggs, CA., et al. 2009. Br J Pharmacol. 158: 1486-94. PMID: 19845675
- In vivo evaluation of alpha7 nicotinic acetylcholine receptor agonists [11C]A-582941 and [11C]A-844606 in mice and conscious monkeys. | Toyohara, J., et al. 2010. PLoS One. 5: e8961. PMID: 20126539
- Repeated administration of alpha7 nicotinic acetylcholine receptor (nAChR) agonists, but not positive allosteric modulators, increases alpha7 nAChR levels in the brain. | Christensen, DZ., et al. 2010. J Neurochem. 114: 1205-16. PMID: 20533993
- Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats. | Thomsen, MS., et al. 2011. PLoS One. 6: e27014. PMID: 22096516
- Type I and II positive allosteric modulators differentially modulate agonist-induced up-regulation of α7 nicotinic acetylcholine receptors. | Thomsen, MS. and Mikkelsen, JD. 2012. J Neurochem. 123: 73-83. PMID: 22804734
- α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. | Medeiros, R., et al. 2014. Am J Pathol. 184: 520-9. PMID: 24269557
- Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors reverse ketamine-induced schizophrenia-like deficits in rats. | Nikiforuk, A., et al. 2016. Neuropharmacology. 101: 389-400. PMID: 26232639
- Pro-cognitive activity in rats of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor. | Potasiewicz, A., et al. 2015. Br J Pharmacol. 172: 5123-35. PMID: 26276349
- α7 nicotinic receptor agonist and positive allosteric modulators differently improved schizophrenia-like cognitive deficits in male rats. | Unal, G., et al. 2021. Behav Brain Res. 397: 112946. PMID: 33011186
Activator of:
AChR α 7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A 582941, 10 mg | sc-362706 | 10 mg | $195.00 | |||
| US: Only available in the US | ||||||
A 582941, 50 mg | sc-362706A | 50 mg | $825.00 | |||
| US: Only available in the US | ||||||