Molecular structure of A 438079 hydrochloride, CAS Number: 899507-36-9
A 438079 hydrochloride (CAS 899507-36-9)
See product citations (13)
Alternate Names:
3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride
Application:
A 438079 hydrochloride is a competitive P2X7 receptor antagonist that is inactive at other P2 receptors
CAS Number:
899507-36-9
Purity:
≥98%
Molecular Weight:
342.61
Molecular Formula:
C13H9Cl2N5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A 438079 hydrochloride is a highly selective antagonist of the P2X7 receptor, which plays a role in mediating inflammation and pain perception through purinergic signaling. By blocking this receptor, A 438079 hydrochloride allows for the examination of ATP′s role in activating immune responses, especially in macrophages and microglia. It inhibits P2X7-mediated signaling, which is critical for understanding how ATP triggers the release of pro-inflammatory cytokines and the formation of the inflammasome. Additionally, its involvement in apoptosis through the regulation of cellular ionic balances facilitates the study of cell death pathways. The use of A 438079 hydrochloride in cellular assays enables the exploration of the effects of P2X7 receptor blockade on cellular signaling pathways, providing a clear view of its basic functions and mechanisms.
A 438079 hydrochloride (CAS 899507-36-9) References
- Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. | Nelson, DW., et al. 2006. J Med Chem. 49: 3659-66. PMID: 16759108
- Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. | Donnelly-Roberts, DL. and Jarvis, MF. 2007. Br J Pharmacol. 151: 571-9. PMID: 17471177
- Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations. | Nörenberg, W., et al. 2011. J Biol Chem. 286: 11067-81. PMID: 21262970
- Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model. | Kobayashi, K., et al. 2011. Neurosci Lett. 504: 57-61. PMID: 21924325
- Genetic analysis of an allergic rhinitis cohort reveals an intercellular epistasis between FAM134B and CD39. | Melchiotti, R., et al. 2014. BMC Med Genet. 15: 73. PMID: 24970562
- ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer's patches to promote host-microbiota mutualism. | Proietti, M., et al. 2014. Immunity. 41: 789-801. PMID: 25464855
- Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P2X7 receptors. | Helliwell, RM., et al. 2015. Br J Pharmacol. 172: 3326-40. PMID: 25752193
- Paroxetine suppresses recombinant human P2X7 responses. | Dao-Ung, P., et al. 2015. Purinergic Signal. 11: 481-90. PMID: 26341077
- Serum Amyloid A1 Is an Epithelial Prorestitutive Factor. | Hinrichs, BH., et al. 2018. Am J Pathol. 188: 937-949. PMID: 29366677
- Blocking P2X7-Mediated Macrophage Polarization Overcomes Treatment Resistance in Lung Cancer. | Qin, J., et al. 2020. Cancer Immunol Res. 8: 1426-1439. PMID: 32933967
- P2RX7 in Dopaminergic Neurons of Ventral Periaqueductal Gray Mediates HTWP Acupuncture-Induced Consciousness in Traumatic Brain Injury. | Tang, H., et al. 2020. Front Cell Neurosci. 14: 598198. PMID: 33519382
- Adipose tissue senescence is mediated by increased ATP content after a short-term high-fat diet exposure. | Pini, M., et al. 2021. Aging Cell. 20: e13421. PMID: 34278707
- The role of P2X7 receptor in infection and metabolism: Based on inflammation and immunity. | Cai, X., et al. 2021. Int Immunopharmacol. 101: 108297. PMID: 34717202
- Characterization of P2X7 Receptors in Human Blood Cells. | Hurtado-Navarro, L., et al. 2022. Methods Mol Biol. 2510: 279-290. PMID: 35776331
- The inhibitory effect of Yam polysaccharides on acrylamide-induced programmed cell death in RAW 264.7 cells. | Wang, J., et al. 2023. Food Sci Nutr. 11: 443-457. PMID: 36655068
- P2X7 receptor antagonist A-438079 alleviates oxidative stress of lung in LPS-induced septic rats. | Ozkanlar, S., et al. 2023. Purinergic Signal.. PMID: 36959434
Inhibitor of:
P2X7.Activator of:
NALP6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A 438079 hydrochloride, 5 mg | sc-203788B | 5 mg | $125.00 | |||
A 438079 hydrochloride, 10 mg | sc-203788 | 10 mg | $215.00 | |||
A 438079 hydrochloride, 25 mg | sc-203788C | 25 mg | $430.00 | |||
A 438079 hydrochloride, 50 mg | sc-203788A | 50 mg | $785.00 |