A-431 + UV Cell Lysate: sc-24656

The A-431 + UV cell lysate is derived from the A-431 cell line, initially established from an epidermoid carcinoma of an 85-year-old female. This specific lysate involves exposure of the A-431 cells to ultraviolet (UV) light, a process that induces a variety of cellular responses, particularly affecting DNA and protein structures. UV exposure is commonly used in research to study cellular stress responses, DNA repair mechanisms, and the activation of signal transduction pathways related to cell damage and apoptosis. By treating these cells with UV light before lysate preparation, researchers can observe the effects of UV-induced cellular damage and the subsequent biological responses. This includes the activation of stress response pathways, upregulation of repair proteins, and changes in cell cycle regulation. The A-431 + UV cell lysate thus serves as a valuable tool for scientists focusing on the molecular biology of stress responses and DNA repair, as well as the study of proteins involved in these processes. It allows for an in-depth analysis of protein expression and post-translational modifications triggered by UV exposure, helping to explain the complex networks by which cells maintain homeostasis and integrity under conditions of environmental stress.