Molecular structure of A-412997 dihydrochloride
A-412997 dihydrochloride (CAS 630116-49-3)
Alternate Names:
N-(3-Methylphenyl)-2-[4-(2-pyridinyl)-1-piperidinyl]acetamide dihydrochloride
Application:
A-412997 dihydrochloride is a selective agonist of the dopamine D4 receptor
CAS Number:
630116-49-3
Molecular Weight:
382.33
Molecular Formula:
C19H23N3O•2HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
A-412997 dihydrochloride is a selective agonist of the dopamine D4 receptor.
A-412997 dihydrochloride (CAS 630116-49-3) References
- A-412997 is a selective dopamine D4 receptor agonist in rats. | Moreland, RB., et al. 2005. Pharmacol Biochem Behav. 82: 140-7. PMID: 16153699
- A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats. | Browman, KE., et al. 2005. Pharmacol Biochem Behav. 82: 148-55. PMID: 16154186
- Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat. | Woolley, ML., et al. 2008. Behav Pharmacol. 19: 765-76. PMID: 19020411
- Putative therapeutic targets for symptom subtypes of adult ADHD: D4 receptor agonism and COMT inhibition improve attention and response inhibition in a novel translational animal model. | Tomlinson, A., et al. 2015. Eur Neuropsychopharmacol. 25: 454-67. PMID: 25799918
- Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. | Chen, Y., et al. 2016. Sci Signal. 9: ra74. PMID: 27460988
- Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung. | Wang, W., et al. 2019. Immunity. 51: 1102-1118.e7. PMID: 31757673
- Dopamine D4 receptors in the lateral habenula regulate depression-related behaviors via a pre-synaptic mechanism in experimental Parkinson's disease. | Hui, Y., et al. 2020. Neurochem Int. 140: 104844. PMID: 32891683
- Heteromerization between α2A adrenoceptors and different polymorphic variants of the dopamine D4 receptor determines pharmacological and functional differences. Implications for impulsive-control disorders. | Casadó-Anguera, V., et al. 2021. Pharmacol Res. 170: 105745. PMID: 34182128
- The Dopamine D4 Receptor Regulates Gonadotropin-Releasing Hormone Neuron Excitability in Male Mice. | Dairaghi, L., et al. 2022. eNeuro. 9: PMID: 35165199
Activator of:
D4DR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A-412997 dihydrochloride, 10 mg | sc-396639 | 10 mg | $108.00 | |||
A-412997 dihydrochloride, 50 mg | sc-396639A | 50 mg | $583.00 |