Molecular structure of A 205804, CAS Number: 251992-66-2
A 205804 (CAS 251992-66-2)
See product citations (2)
Alternate Names:
4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide
Application:
A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression
CAS Number:
251992-66-2
Purity:
≥98%
Molecular Weight:
300.39
Molecular Formula:
C15H12N2OS2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression (IC50 values are 20, 25 and > 1000 nM for TNF-alpha-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.
A 205804 (CAS 251992-66-2) References
- Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. | Stewart, AO., et al. 2001. J Med Chem. 44: 988-1002. PMID: 11300880
- Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. | Zhu, GD., et al. 2001. J Med Chem. 44: 3469-87. PMID: 11585452
- Synthesis and mode of action of (125)I- and (3)H-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression. | Zhu, GD., et al. 2002. J Org Chem. 67: 943-8. PMID: 11856042
- Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and Plasmodium falciparum. | Bhalla, K., et al. 2015. Nat Commun. 6: 6049. PMID: 25586702
- CTC clusters induced by heparanase enhance breast cancer metastasis. | Wei, RR., et al. 2018. Acta Pharmacol Sin. 39: 1326-1337. PMID: 29417941
- RUNX transcription factors potentially control E-selectin expression in the bone marrow vascular niche in mice. | Morita, K., et al. 2018. Blood Adv. 2: 509-515. PMID: 29500219
- Cathepsin D enhances breast cancer invasion and metastasis through promoting hepsin ubiquitin-proteasome degradation. | Zhang, C., et al. 2018. Cancer Lett. 438: 105-115. PMID: 30227221
- Interactions between rheumatoid arthritis synovial fibroblast migration and endothelial cells. | Zimmermann-Geller, B., et al. 2019. Immunol Cell Biol. 97: 178-189. PMID: 30252968
- Evidence of Accumulated Endothelial Progenitor Cells in the Lungs of Rats with Pulmonary Arterial Hypertension by 89Zr-oxine PET Imaging. | Liu, Y., et al. 2020. Mol Ther Methods Clin Dev. 17: 1108-1117. PMID: 32490032
- Adhesion Promotes Allergic Rhinitis CD4+IL4+ T Cell Differentiation via ICAM1 and E-Selectin. | Liu, H., et al. 2022. Am J Rhinol Allergy. 19458924221086061. PMID: 35296145
- New Insight into Drugs to Alleviate Atopic March via Network Pharmacology-Based Analysis. | Oh, KK., et al. 2022. Curr Issues Mol Biol. 44: 2257-2274. PMID: 35678682
- A Novel Pathway for Porcine Epidemic Diarrhea Virus Transmission from Sows to Neonatal Piglets Mediated by Colostrum. | Yuan, C., et al. 2022. J Virol. 96: e0047722. PMID: 35758666
- The mechanism underlying ICAM-1 and E-selectin-mediated hypertriglyceridemic pancreatitis-associated lung injury. | Yu, R., et al. 2022. Mol Immunol. 152: 55-66. PMID: 36279659
- HLA class II antibody activation of endothelial cells induces M2 macrophage differentiation in peripheral blood. | Guo, Y., et al. 2023. Clin Exp Nephrol. 27: 309-320. PMID: 36611129
- ERβ promoted invadopodia formation-mediated non-small cell lung cancer metastasis via the ICAM1/p-Src/p-Cortactin signaling pathway. | Wang, Y., et al. 2023. Int J Cancer.. PMID: 37212571
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A 205804, 10 mg | sc-203484 | 10 mg | $143.00 | |||
A 205804, 50 mg | sc-203484A | 50 mg | $592.00 |