Molecular structure of A-1331852, CAS Number: 1430844-80-6
A-1331852 (CAS 1430844-80-6)
Alternate Names:
6-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid
CAS Number:
1430844-80-6
Molecular Weight:
658.8
Molecular Formula:
C38H38N6O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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A-1331852 (CAS 1430844-80-6) References
- BH3 profiling identifies BCL-2 dependence in adult patients with early T-cell progenitor acute lymphoblastic leukemia. | Olesinski, EA., et al. 2023. Blood Adv. 7: 2917-2923. PMID: 36763538
- Single-molecule fingerprinting of protein-drug interaction using a funneled biological nanopore. | Jeong, KB., et al. 2023. Nat Commun. 14: 1461. PMID: 37015934
- BCL2L1 inhibitor A-1331852 inhibits MCL1 transcription and triggers apoptosis in acute myeloid leukemia cells. | Chiou, JT., et al. 2023. Biochem Pharmacol. 215: 115738. PMID: 37562509
- Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy. | Yin, L., et al. 2024. Life Sci Alliance. 7: PMID: 38316463
- BCL-XL inhibitors enhance the apoptotic efficacy of BRAF inhibitors in BRAFV600E colorectal cancer. | Jenkins, LJ., et al. 2024. Cell Death Dis. 15: 183. PMID: 38429301
- Senolysis of gemcitabine-induced senescent human pancreatic cancer cells. | Hoque, MM., et al. 2024. Cancer Rep (Hoboken). 7: e2075. PMID: 38662379
- Metabolic signature and response to glutamine deprivation are independent of p53 status in B cell malignancies. | Montironi, C., et al. 2024. iScience. 27: 109640. PMID: 38680661
- Decreased apoptotic priming and loss of BCL-2 dependence are functional hallmarks of Richter's syndrome. | Rigo, A., et al. 2024. Cell Death Dis. 15: 323. PMID: 38724507
- Profiling of BCLxL Protein Complexes in Non-Small Cell Lung Cancer Cells via Multiplexed Single-Molecule Pull-Down and Co-Immunoprecipitation. | Kim, SH., et al. 2024. Anal Chem. 96: 8932-8941. PMID: 38728439
- Improved drug target deconvolution with PISA-DIA using an extended, overlapping temperature gradient. | Emery-Corbin, SJ., et al. 2024. Proteomics. e2300644. PMID: 38766901
Inhibitor of:
Bcl-2, Bcl-7c, Bcl-B, Bcl-xl, FAM136B, GOLT1B, MOMP, and Snf2.Activator of:
Bax, and Hrk.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A-1331852, 5 mg | sc-507472 | 5 mg | $230.00 |