9Z,11E,13E-Octadecatrienoic Acid ethyl ester (CAS 42021-86-3)
QUICK LINKS
9Z,11E,13E-Octadecatrienoic Acid ethyl ester is a conjugated polyunsaturated fatty acid found in plant seed oil which accounts for about 70% in tung oil and 60% of the total fatty acid composition of bitter gourd seed oil. alpha-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, alpha-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARgamma. In DLD-1 cells supplemented with alpha-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 µM. It also inhibits DNA polymerases and Topo (topoisomerases) with IC50s ranging from ~5-20 muM for different isoforms of the enzymes. alpha-ESA ethyl ester is a neutral, more lipid soluble form of the free acid.
9Z,11E,13E-Octadecatrienoic Acid ethyl ester (CAS 42021-86-3) References
- Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen-induced acute liver injury in BALB/c mice. | Park, DW., et al. 2021. Toxicol Res. 37: 261-275. PMID: 33868982
- Metabolite fingerprinting of the ripening process in Pixian douban using a feature-based molecular network and metabolomics analysis. | Li, W., et al. 2023. Food Chem. 418: 135940. PMID: 36965392
- Malaysian brown macroalga Padina australis mitigates lipopolysaccharide-stimulated neuroinflammation in BV2 microglial cells. | Subermaniam, K., et al. 2023. Iran J Basic Med Sci. 26: 669-679. PMID: 37275754
- Microbial Communities and Metabolites of Whole Crop Corn Silage Inoculated with Lentilactobacillus plantarum and Lentilactobacillus buchneri | Guo, Q., et al. 2022. Processes. 10(11): 2369.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
9Z,11E,13E-Octadecatrienoic Acid ethyl ester, 1 mg | sc-205198 | 1 mg | $92.00 | |||
9Z,11E,13E-Octadecatrienoic Acid ethyl ester, 100 mg | sc-205198A | 100 mg | $224.00 |