Molecular structure of 9α,11β-PGF2 (9α,11β-Prostaglandin F2), CAS Number: 38432-87-0
9α,11β-PGF2 (9α,11β-Prostaglandin F2) (CAS 38432-87-0)
Application:
9α,11β-PGF2 (9α,11β-Prostaglandin F2) is platelet aggregation and adipose differentiation inhibitor
CAS Number:
38432-87-0
Molecular Weight:
354.48
Molecular Formula:
C20H34O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
9α,11β-PGF2 (9α,11β-Prostaglandin F2), a prostaglandin metabolite that is enzymatically formed in the liver, lung, and kidneys, has been reported to cause constriction of canine coronary artery strips and inhibit platelet aggregation. Additional experiments have shown that this compound is also a potent bronchoconstrictor agent of human airways and isolated guinea pig trachea in vitro. Other studies have noted that 9α,11β-Prostaglandin F2 demonstrates the ability to be a potent adipose differentiation inhibitor which causes adipocyte tissue growth interference.
9α,11β-PGF2 (9α,11β-Prostaglandin F2) (CAS 38432-87-0) References
- Urinary leukotriene E4 and 9 alpha, 11 beta-prostaglandin F concentrations in mild, moderate and severe asthma, and in healthy subjects. | Misso, NL., et al. 2004. Clin Exp Allergy. 34: 624-31. PMID: 15080817
- Identification of 9alpha,11beta-prostaglandin F2 in human amniotic fluid and characterization of its production by human gestational tissues. | Mitchell, MD., et al. 2005. J Clin Endocrinol Metab. 90: 4244-8. PMID: 15840748
- Leptin and urinary leukotriene E4 and 9α,11β-prostaglandin F2 release after exercise challenge. | Baek, HS., et al. 2013. Ann Allergy Asthma Immunol. 111: 112-7. PMID: 23886229
- Urinary excretion of 9α,11β-prostaglandin F2 and leukotriene E4 in patients with exercise-induced bronchoconstriction. | Shin, TR., et al. 2015. J Thorac Dis. 7: 1198-204. PMID: 26380736
- Omalizumab reduces cysteinyl leukotriene and 9α,11β-prostaglandin F2 overproduction in aspirin-exacerbated respiratory disease. | Hayashi, H., et al. 2016. J Allergy Clin Immunol. 137: 1585-1587.e4. PMID: 26559322
- Metabolism of prostaglandin D2 in isolated rat lung: the stereospecific formation of 9 alpha,11 beta-prostaglandin F2 from prostaglandin D2. | Hayashi, H., et al. 1987. Biochim Biophys Acta. 917: 356-64. PMID: 3467796
- 9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways. | Beasley, CR., et al. 1987. J Clin Invest. 79: 978-83. PMID: 3469218
- Renal response to 9 alpha, 11 beta-prostaglandin F2 in the rat. | Stier, CT., et al. 1987. J Pharmacol Exp Ther. 243: 487-91. PMID: 3479549
- Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans. | Liston, TE. and Roberts, LJ. 1985. Proc Natl Acad Sci U S A. 82: 6030-4. PMID: 3862115
- Hepatic transformation of prostaglandin D2 to a new prostanoid, 9 alpha,11 beta-prostaglandin F2, that inhibits platelet aggregation and constricts blood vessels. | Pugliese, G., et al. 1985. J Biol Chem. 260: 14621-5. PMID: 3863819
- Reduction of prostaglandin D2 to 9 alpha,11 beta-prostaglandin F2 by a human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isozyme. | Ohara, H., et al. 1994. Biochim Biophys Acta. 1215: 59-65. PMID: 7948008
- Inhibition of adipose differentiation by 9 alpha, 11 beta-prostaglandin F2 alpha. | Lepak, NM. and Serrero, G. 1993. Prostaglandins. 46: 511-7. PMID: 8295981
- Increased urinary excretion of the prostaglandin D2 metabolite 9 alpha, 11 beta-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway obstruction. | O'Sullivan, S., et al. 1996. J Allergy Clin Immunol. 98: 421-32. PMID: 8757220
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
9α,11β-PGF2 (9α,11β-Prostaglandin F2), 1 mg | sc-201246 | 1 mg | $192.00 | |||
9α,11β-PGF2 (9α,11β-Prostaglandin F2), 5 mg | sc-201246B | 5 mg | $770.00 | |||
9α,11β-PGF2 (9α,11β-Prostaglandin F2), 10 mg | sc-201246A | 10 mg | $1740.00 |