9(S)-HODE (CAS 73543-67-6)

9(S)-HODE, with CAS number 73543-67-6, is the S-enantiomer of 9-hydroxyoctadecadienoic acid, a hydroxy fatty acid derived from the oxidation of linoleic acid primarily through the action of lipoxygenases. This specific enantiomer is a focus in biochemical and molecular biology research due to its involvement in the modulation of various cellular signaling pathways. 9(S)-HODE is known for its role in interacting with cellular receptors such as peroxisome proliferator-activated receptors (PPARs), which are critical in the regulation of lipid metabolism and inflammation. Its ability to activate or inhibit these receptors provides a valuable tool for researchers to investigate the mechanisms through which oxidized fatty acids can influence cellular functions like differentiation, proliferation, and apoptosis. In research settings, 9(S)-HODE is often used to study its effects on signaling pathways that regulate oxidative stress responses and to explore its potential implications in the modulation of the inflammatory processes. The insights gained from studies involving 9(S)-HODE are crucial for understanding the broader roles of lipid oxidation products in cellular homeostasis and the complex networks of signal transduction they influence, providing key observations on the biochemical behaviors of lipids within biological systems.