9(R)-HODE (CAS 10075-11-3)

9(R)-HODE, cataloged under the CAS number 10075-11-3, is the R-enantiomer of 9-hydroxyoctadecadienoic acid, a metabolite derived from the oxidation of linoleic acid predominantly through the enzymatic activity of 9-lipoxygenases. This specific enantiomer is of considerable interest in biochemical research due to its distinct biological activities compared to its S-enantiomer. 9(R)-HODE is involved in modulating cellular processes through its interaction with peroxisome proliferator-activated receptors (PPARs), which play a crucial role in the regulation of gene expression linked to lipid metabolism and cellular energy homeostasis. The compound′s ability to activate these receptors allows researchers to study its influence on lipid signaling pathways and its potential role in modulating inflammatory responses at the cellular level. In research contexts, 9(R)-HODE is particularly valued for its utility in exploring the mechanisms of lipid-mediated cellular regulation, contributing to a deeper understanding of the molecular basis of lipid signaling and its impact on cellular physiology. Investigations using 9(R)-HODE help explain how specific lipid molecules can affect cell function, providing insights that are crucial for understanding complex biological systems and their response to various biochemical stimuli.