Molecular structure of 9-Phenanthrol, CAS Number: 484-17-3
9-Phenanthrol (CAS 484-17-3)
See product citations (2)
Alternate Names:
9-Hydroxyphenanthrene
Application:
9-Phenanthrol is a Phenanthrene metabolite
CAS Number:
484-17-3
Molecular Weight:
194.23
Molecular Formula:
C14H10O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
9-Phenanthrol is a metabolite of Phenanthrene, which functions as a selective inhibitor of TRPM4. TRPM4 are calcium activated channels, located in several tissues such as the heart, kidney, brainstem, cerebral artery and immune system. Studies indicate that TRPM4 regulates smooth muscle cell membrane depolarization. In addition, 9-Phenanthrol is an important tool to monitor the effects of this receptor on smooth muscle cells. Furthermore, studies on cerebral artery myocytes suggest that 9-Phenanthrol reduces transient inward cation currents, which are induced by TRPM4.
9-Phenanthrol (CAS 484-17-3) References
- 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. | Grand, T., et al. 2008. Br J Pharmacol. 153: 1697-705. PMID: 18297105
- Ca2+ release from the sarcoplasmic reticulum is required for sustained TRPM4 activity in cerebral artery smooth muscle cells. | Gonzales, AL., et al. 2010. Am J Physiol Cell Physiol. 299: C279-88. PMID: 20427713
- Pharmacological inhibition of TRPM4 hyperpolarizes vascular smooth muscle. | Gonzales, AL., et al. 2010. Am J Physiol Cell Physiol. 299: C1195-202. PMID: 20826763
- 9-Phenanthrol modulates postinhibitory rebound and afterhyperpolarizing potentials in an excitatory motor neuron of the medicinal leech. | Angstadt, JD., et al. 2017. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 203: 613-633. PMID: 28497254
- 9-Phenanthrol enhances the generation of an CD8+ T cell response following transcutaneous immunization with imiquimod in mice. | Hartmann, AK., et al. 2017. J Dermatol Sci. 87: 260-267. PMID: 28823644
- A TRPM4 Inhibitor 9-Phenanthrol Inhibits Glucose- and Glucagon-Like Peptide 1-Induced Insulin Secretion from Rat Islets of Langerhans. | Ma, Z., et al. 2017. J Diabetes Res. 2017: 5131785. PMID: 29098165
- The transient receptor potential melastatin 4 channel inhibitor 9-phenanthrol modulates cardiac sodium channel. | Hou, JW., et al. 2018. Br J Pharmacol. 175: 4325-4337. PMID: 30153324
- TRPM4 channel inhibitors 9-phenanthrol and glibenclamide differentially decrease guinea pig detrusor smooth muscle whole-cell cation currents and phasic contractions. | Malysz, J., et al. 2020. Am J Physiol Cell Physiol. 318: C406-C421. PMID: 31851526
- Preparation and Utilization of Freshly Isolated Human Detrusor Smooth Muscle Cells for Characterization of 9-Phenanthrol-Sensitive Cation Currents. | Malysz, J., et al. 2020. J Vis Exp.. PMID: 32065126
- Transcriptome and Quasi-Targeted Metabolome Analyze Overexpression of 4-Hydroxyphenylpyruvate Dioxygenase Alleviates Fungal Toxicity of 9-Phenanthrol in Magnaporthe oryzae. | Wang, Y., et al. 2022. Int J Mol Sci. 23: PMID: 35806121
- Differential effects of TRPM4 channel inhibitors on Guinea pig urinary bladder smooth muscle excitability and contractility: Novel 4-chloro-2-[2-(2-chloro-phenoxy)-acetylamino]-benzoic acid (CBA) versus classical 9-phenanthrol. | Malysz, J., et al. 2022. Pharmacol Res Perspect. 10: e00982. PMID: 35822549
- Excellent removal performance of 4,4'-biphenyldicarboxaldehyde m-phenylenediamine Schiff base magnetic polymer towards phenanthrene and 9-phenanthrol: Experimental, modeling and DFT calculations studies. | Wei, Z., et al. 2023. J Hazard Mater. 441: 129920. PMID: 36099739
- The TRPM4 channel inhibitor 9-phenanthrol alleviates cerebral edema after traumatic brain injury in rats. | Ma, P., et al. 2023. Front Pharmacol. 14: 1098228. PMID: 36865920
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
9-Phenanthrol, 10 mg | sc-207225 | 10 mg | $440.00 |