9-Hydroxyellipticine, Hydrochloride (CAS 52238-35-4)
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9-Hydroxyellipticine, Hydrochloride is a cell-permeable antitumor alkaloid that acts as a potent inhibitor of Topo II (IC50 = 3.3 muM). Restores functional wild-type p53 activity via inhibition of mutant p53 protein phosphorylation. Suppresses Cdk2 activity in a concentration-dependent manner. Also reported to inhibit telomerase activity in cultured pancreatic cells, possibly through inhibition of protein kinases. Binds to the aryl hydrocarbon receptor (AhR) in rat lung cytosol and inhibits aryl hydrocarbon hydroxylase (AHH) activity in rat hepatic microsomes. 9-Hydroxyellipticine, Hydrochloride analogs are synthetic compounds derived from the natural alkaloid ellipticine. These analogs have garnered attention for their potential in combating inflammation.
9-Hydroxyellipticine, Hydrochloride (CAS 52238-35-4) References
- Transfection of 9-hydroxyellipticine-resistant Chinese hamster fibroblasts with human topoisomerase IIalpha cDNA: selective restoration of the sensitivity to DNA religation inhibitors. | Khélifa, T., et al. 1999. Cancer Res. 59: 4927-36. PMID: 10519406
- Design, synthesis and evaluation of human telomerase inhibitors based upon a tetracyclic structural motif. | Perry, PJ., et al. 1999. Anticancer Drug Des. 14: 373-82. PMID: 10625930
- Mutant p53 mediated induction of cell cycle arrest and apoptosis at G1 phase by 9-hydroxyellipticine. | Sugikawa, E., et al. 1999. Anticancer Res. 19: 3099-108. PMID: 10652599
- Diverse effects of 9-hydroxyellipticine on the chemosensitivity of human pancreatic cancer cells harboring p53 mutations. | Mizumoto, K., et al. 2000. Cancer Lett. 149: 85-94. PMID: 10737712
- 9-Hydroxyellipticine alters the conformation and DNA binding characteristics of mutated p53 protein. | Sugikawa, E., et al. 2001. Anticancer Res. 21: 2671-5. PMID: 11724337
- Cardioprotective effects of 9-hydroxyellipticine on ischemia and reperfusion in isolated rat heart. | Saeki, K., et al. 2002. Jpn J Pharmacol. 89: 21-8. PMID: 12083739
- In vivo exposure to four ellipticine derivatives with topoisomerase inhibitory activity results in chromosome clumping and sister chromatid exchange in murine bone marrow cells. | Renault, G., et al. 1987. Toxicol Appl Pharmacol. 89: 281-6. PMID: 3037729
- Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. | Ohashi, M., et al. 1995. Jpn J Cancer Res. 86: 819-27. PMID: 7591958
- Theoretical studies of the intercalation of 9-hydroxyellipticine in DNA. | Elcock, AH., et al. 1996. Biopolymers. 39: 309-26. PMID: 8756512
- Spectroscopic studies of 9-hydroxyellipticine binding to DNA. | Ismail, MA., et al. 1998. Biopolymers. 46: 127-43. PMID: 9741963
- 9-Hydroxyellipticine inhibits telomerase activity in human pancreatic cancer cells. | Sato, N., et al. 1998. FEBS Lett. 441: 318-21. PMID: 9883907
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
9-Hydroxyellipticine, Hydrochloride, 10 mg | sc-203940 | 10 mg | $510.00 | |||
9-Hydroxyellipticine, Hydrochloride, 50 mg | sc-203940A | 50 mg | $1638.00 |