Molecular structure of 9-Ethylguanine, CAS Number: 879-08-3
9-Ethylguanine (CAS 879-08-3)
Alternate Names:
2-Amino-9-ethyl-6-hydroxypurine; 6-Amino-9-ethyl-2-hydroxypurine; 9-EtG
Application:
9-Ethylguanine is used to study DNA interactions with organometallic complexes
CAS Number:
879-08-3
Molecular Weight:
179.18
Molecular Formula:
C7H9N5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
9-Ethylguanine functions as a mutagenic agent. It exerts its mechanism of action by incorporating into DNA during replication, leading to the formation of abnormal base pairs. This can result in the induction of mutations, which can be studied to understand the effects of DNA damage and repair processes. 9-Ethylguanine interferes with the accurate replication of genetic information, contributing to the generation of genetic diversity and the study of mutagenesis. Its role in inducing mutations investigates the mechanisms of DNA repair and the consequences of DNA damage at the molecular level. By serving as a mutagenic agent, 9-Ethylguanine contributes to the study of genetic variation and the processes involved in maintaining genomic stability.
9-Ethylguanine (CAS 879-08-3) References
- Coordination of 9-ethylguanine to the mixed-ligand compound alpha-[Ru(azpy)(bpy)Cl2] (azpy = 2-phenylazopyridine and bpy = 2,2'-bipyridine). An unprecedented ligand positional shift, correlated to the cytotoxicity of this type of [RuL2Cl2] (with L = azpy or bpy) complex. | Hotze, AC., et al. 2004. Inorg Chem. 43: 4935-43. PMID: 15285670
- Model platinum nucleobase and nucleoside complexes and antitumor activity: X-ray crystal structure of [PtIV(trans-1R,2R-diaminocyclohexane)trans-(acetate)2(9-ethylguanine)Cl]NO3.H2O. | Ali, MS., et al. 2005. J Inorg Biochem. 99: 795-804. PMID: 15708801
- Chlorido-, aqua-, 9-ethylguanine- and 9-ethyladenine-adducts of cytotoxic ruthenium arene complexes containing O,O-chelating ligands. | Melchart, M., et al. 2007. J Inorg Biochem. 101: 1903-12. PMID: 17582501
- Interaction between the DNA model base 9-ethylguanine and a group of ruthenium polypyridyl complexes: kinetics and conformational temperature dependence. | Corral, E., et al. 2007. Inorg Chem. 46: 6715-22. PMID: 17616123
- Ruthenium polypyridyl complexes and their modes of interaction with DNA: is there a correlation between these interactions and the antitumor activity of the compounds? | Corral, E., et al. 2009. J Biol Inorg Chem. 14: 439-48. PMID: 19085018
- Organometallic half-sandwich iridium anticancer complexes. | Liu, Z., et al. 2011. J Med Chem. 54: 3011-26. PMID: 21443199
- Interaction of liposome-encapsulated cisplatin with biomolecules. | Baruah, B. and Surin, A. 2012. J Biol Inorg Chem. 17: 899-910. PMID: 22674433
- Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes. | Hanif, M., et al. 2013. Front Chem. 1: 27. PMID: 24790955
- Guanine tetrads: an IRMPD spectroscopy, energy resolved SORI-CID, and computational study of M(9-ethylguanine)(4)(+) (M = Li, Na, K, Rb, Cs) in the gas phase. | Azargun, M. and Fridgen, TD. 2015. Phys Chem Chem Phys. 17: 25778-85. PMID: 25845669
- Unusual Example of Chelate Ring Opening upon Coordination of the 9-Ethylguanine Nucleobase to [Pt(di-(6-methyl-2-picolyl)amine)Cl]Cl. | Andrepont, C., et al. 2015. Inorg Chem. 54: 4895-908. PMID: 25910178
- Contrasting Anticancer Activity of Half-Sandwich Iridium(III) Complexes Bearing Functionally Diverse 2-Phenylpyridine Ligands. | Millett, AJ., et al. 2015. Organometallics. 34: 2683-2694. PMID: 26146437
- Synthesis and X-ray crystal structure of the dirhenium complex Re2(i-C3H7COO)4Cl2 and its interactions with the DNA purine nucleobases. | Shtemenko, AV., et al. 2015. J Inorg Biochem. 153: 114-120. PMID: 26315264
- Hydrosulfide Adducts of Organo-Iridium Anticancer Complexes. | Štarha, P., et al. 2016. Inorg Chem. 55: 2324-31. PMID: 26863200
- The K2(9-ethylguanine)122+ quadruplex is more stable to unimolecular dissociation than the K(9-ethylguanine)8+ quadruplex in the gas phase: a BIRD, energy resolved SORI-CID, IRMPD spectroscopic, and computational study. | Azargun, M., et al. 2019. Phys Chem Chem Phys. 21: 15319-15326. PMID: 31243401
- Phosphate-guanosine interactions. A model for the involvement of guanine derivatives in autocatalytic reactions of ribonucleic acids. | Lancelot, G. and Hélène, C. 1984. J Biol Chem. 259: 15046-50. PMID: 6210285
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
9-Ethylguanine, 100 mg | sc-207221 | 100 mg | $107.00 |