9-Cyclopentyladenine monomethanesulfonate (CAS 189639-09-6)
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9-Cyclopentyladenine monomethanesulfonate operates as a stable, cell-permeable entity that plays a pivotal role in modulating cellular signaling pathways, particularly by exerting its influence on the P-site domain of adenylyl cyclase, a enzyme in the synthesis of cyclic AMP (cAMP) from ATP. This action categorizes it as a non-competitive inhibitor, meaning it binds to a site other than the active site of the enzyme, leading to an alteration in enzymatic activity without competing with substrate binding. Its efficacy and specificity have been demonstrated in studies utilizing detergent-dispersed rat brain preparations, where it exhibits an inhibition concentration (IC50) of 100 muM. This characteristic highlights its utility in research applications focused on dissecting the nuanced roles of cAMP-mediated signaling pathways, offering insights into cellular processes regulated by this critical second messenger.
9-Cyclopentyladenine monomethanesulfonate (CAS 189639-09-6) References
- Relaxin influences ileal muscular activity through a dual signaling pathway in mice. | Idrizaj, E., et al. 2018. World J Gastroenterol. 24: 882-893. PMID: 29491682
- Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated inhibition by adenine nucleosides and nucleoside 3'-polyphosphates. | Johnson, RA., et al. 1997. J Biol Chem. 272: 8962-6. PMID: 9083018
- Adenylyl cyclase P-site ligands accelerate differentiation in Ob1771 preadipocytes. | Ibrahimi, A., et al. 1999. Am J Physiol. 276: C487-96. PMID: 9950777
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
9-Cyclopentyladenine monomethanesulfonate, 5 mg | sc-214435 | 5 mg | $426.00 | |||
9-Cyclopentyladenine monomethanesulfonate, 25 mg | sc-214435A | 25 mg | $1665.00 |