Date published: 2026-2-2

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9-cis Retinol (CAS 22737-97-9)

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Alternate Names:
9-cis-Retinol; 9-cis-Vitamin A Alcohol
Application:
9-cis Retinol is a metabolite of Vitamin A
CAS Number:
22737-97-9
Purity:
≥95%
Molecular Weight:
286.45
Molecular Formula:
C20H30O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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9-cis Retinol is a metabolite of Vitamin A that has been used to study the role of Vitamin A in vision, growth, and development. Furthermore, it has been employed to investigate the involvement of Vitamin A in the regulation of gene expression, cell proliferation, and cell differentiation. It can easily be incorporated into various cell culture systems.


9-cis Retinol (CAS 22737-97-9) References

  1. Characterization of a new member of the fatty acid-binding protein family that binds all-trans-retinol.  |  Vogel, S., et al. 2001. J Biol Chem. 276: 1353-60. PMID: 11022035
  2. Structure, promoter and chromosomal localization of rdh6.  |  Chai, X., et al. 2001. Gene. 274: 27-33. PMID: 11674995
  3. cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a short-chain dehydrogenase active in a reconstituted path of 9-cis-retinoic acid biosynthesis in intact cells.  |  Zhuang, R., et al. 2002. Biochemistry. 41: 3477-83. PMID: 11876656
  4. Targeted disruption of the mouse cis-retinol dehydrogenase gene: visual and nonvisual functions.  |  Shang, E., et al. 2002. J Lipid Res. 43: 590-7. PMID: 11907141
  5. Gene structure and minimal promoter of mouse rdh1.  |  Zhang, M., et al. 2003. Gene. 305: 121-31. PMID: 12594048
  6. Intracellular signaling by 14-hydroxy-4,14-retro-retinol.  |  Buck, J., et al. 1991. Science. 254: 1654-6. PMID: 1749937
  7. Binding affinities of CRBPI and CRBPII for 9-cis-retinoids.  |  Kane, MA., et al. 2011. Biochim Biophys Acta. 1810: 514-8. PMID: 21382444
  8. cis Retinol oxidation regulates photoreceptor access to the retina visual cycle and cone pigment regeneration.  |  Sato, S. and Kefalov, VJ. 2016. J Physiol. 594: 6753-6765. PMID: 27385534
  9. Identification of 5,6-epoxyretinoic acid as an endogenous retinol metabolite.  |  McCormick, AM. and Napoli, JL. 1982. J Biol Chem. 257: 1730-5. PMID: 7056740
  10. 9-Cis beta-carotene as a precursor of retinol isomers in chicks.  |  Levin, G. and Mokady, S. 1994. Int J Vitam Nutr Res. 64: 165-9. PMID: 7814229
  11. A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid.  |  Labrecque, J., et al. 1995. Biochem J. 305 (Pt 2): 681-4. PMID: 7832787
  12. Specificity of the retinol transporter of the rat small intestine brush border.  |  Dew, SE. and Ong, DE. 1994. Biochemistry. 33: 12340-5. PMID: 7918456
  13. Biochemical pathways of retinoid transport, metabolism, and signal transduction.  |  Napoli, JL. 1996. Clin Immunol Immunopathol. 80: S52-62. PMID: 8811064
  14. cDNA cloning and characterization of a cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase.  |  Chai, X., et al. 1997. J Biol Chem. 272: 33125-31. PMID: 9407098
  15. Retinoids, omega-hydroxyfatty acids and cytotoxic aldehydes as physiological substrates, and H2-receptor antagonists as pharmacological inhibitors, of human class IV alcohol dehydrogenase.  |  Allali-Hassani, A., et al. 1998. FEBS Lett. 426: 362-6. PMID: 9600267

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

9-cis Retinol, 2 mg

sc-210706D
2 mg
$320.00

9-cis Retinol, 5 mg

sc-210706
5 mg
$484.00

9-cis Retinol, 10 mg

sc-210706A
10 mg
$770.00

9-cis Retinol, 25 mg

sc-210706B
25 mg
$1600.00

9-cis Retinol, 50 mg

sc-210706C
50 mg
$3512.00

I would like to know the absorbance peak of 9-cis retinol

Asked by: Aviv
Thank you for contacting Santa Cruz Biotechnology. We are unable to provide analytical data.
Answered by: BlakeJ
Date published: 2025-07-25
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Rated 5 out of 5 by from Performed to our standardPerformed to our standard. Good quality.
Date published: 2015-10-12
Rated 5 out of 5 by from WolfWolf, G. (PubMed 11140907) reported a new short-chain alcohol dehydrogenase that is capable of oxidizing 9-cis Retinol to its corresponding aldehydes. -SCBT Publication Review
Date published: 2015-03-02
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9-cis Retinol is rated 5.0 out of 5 by 2.
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