Molecular structure of 9-Aminocamptothecin, CAS Number: 91421-43-1
9-Aminocamptothecin (CAS 91421-43-1)
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Alternate Names:
9-amino-20-camptothecin, (R,S)-isomer
Application:
9-Aminocamptothecin is an active derivative of camptothecin and topoisomerase inhibitor
CAS Number:
91421-43-1
Purity:
≥95%
Molecular Weight:
363.37
Molecular Formula:
C20H17N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
9-Aminocamptothecin is an active derivative of camptothecin, which belongs to the general group of chemotherapy drugs called topoisomerase inhibitors.
9-Aminocamptothecin (CAS 91421-43-1) References
- Intraperitoneal topoisomerase-I inhibitors. Preliminary findings with 9-aminocamptothecin. | Muggia, F., et al. 2000. Ann N Y Acad Sci. 922: 178-87. PMID: 11193893
- The clinical development of 9-aminocamptothecin. | Takimoto, CH. and Thomas, R. 2000. Ann N Y Acad Sci. 922: 224-36. PMID: 11193898
- Anti-tumour activity and toxicity of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in mice. | Prijovich, ZM., et al. 2002. Br J Cancer. 86: 1634-8. PMID: 12085215
- Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection. | Schoemaker, NE., et al. 2002. J Chromatogr B Analyt Technol Biomed Life Sci. 775: 231-7. PMID: 12113990
- Differential effects of the breast cancer resistance protein on the cellular accumulation and cytotoxicity of 9-aminocamptothecin and 9-nitrocamptothecin. | Rajendra, R., et al. 2003. Cancer Res. 63: 3228-33. PMID: 12810652
- Cytochrome P450 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: impact on cancer therapy. | Maier-Salamon, A., et al. 2014. Int J Oncol. 45: 877-86. PMID: 24889073
- Radiation lethality enhancement with 9-aminocamptothecin: comparison to other topoisomerase I inhibitors. | Lamond, JP., et al. 1996. Int J Radiat Oncol Biol Phys. 36: 369-76. PMID: 8892462
- 9-Aminocamptothecin and beyond. Preclinical and clinical studies. | Potmesil, M., et al. 1996. Ann N Y Acad Sci. 803: 231-46. PMID: 8993517
- Plasma and cerebrospinal fluid pharmacokinetics of 9-aminocamptothecin (9-AC), irinotecan (CPT-11), and SN-38 in nonhuman primates. | Blaney, SM., et al. 1998. Cancer Chemother Pharmacol. 41: 464-8. PMID: 9554590
- 9-Aminocamptothecin: a topoisomerase I inhibitor with preclinical activity in prostate cancer. | de Souza, PL., et al. 1997. Clin Cancer Res. 3: 287-94. PMID: 9815685
Inhibitor of:
Topo I.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
9-Aminocamptothecin, 10 mg | sc-205615 | 10 mg | $166.00 | |||
9-Aminocamptothecin, 25 mg | sc-205615A | 25 mg | $345.00 |