Date published: 2025-9-30

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8-PIP-cAMP (CAS 31357-06-9)

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Application:
8-PIP-cAMP is a selective cAMP-dependent protein kinase activator
CAS Number:
31357-06-9
Molecular Weight:
434.32
Molecular Formula:
C15H20N6O6PNa
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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A selective cAMP-dependent protein kinase (PKA) activator which is a site selective cyclic AMP analog with high selectivity for the site A of protein kinase A type I and site B of type II. Acts synergistically together with analog having opposite site-selectivity.


8-PIP-cAMP (CAS 31357-06-9) References

  1. The cAMP-dependent protein kinase mediates the expression of AChE in chick myotubes.  |  Choi, RC., et al. 2000. Neuroreport. 11: 801-6. PMID: 10757523
  2. 8-Substituted cAMP analogues reveal marked differences in adaptability, hydrogen bonding, and charge accommodation between homologous binding sites (AI/AII and BI/BII) in cAMP kinase I and II.  |  Schwede, F., et al. 2000. Biochemistry. 39: 8803-12. PMID: 10913291
  3. Adenosine-mediated inhibition of the cytotoxic activity and cytokine production by activated natural killer cells.  |  Lokshin, A., et al. 2006. Cancer Res. 66: 7758-65. PMID: 16885379
  4. Inhibition of cytokine production and cytotoxic activity of human antimelanoma specific CD8+ and CD4+ T lymphocytes by adenosine-protein kinase A type I signaling.  |  Raskovalova, T., et al. 2007. Cancer Res. 67: 5949-56. PMID: 17575165
  5. Different expression of protein kinase A (PKA) regulatory subunits in cortisol-secreting adrenocortical tumors: relationship with cell proliferation.  |  Mantovani, G., et al. 2008. Exp Cell Res. 314: 123-30. PMID: 17904549
  6. High expression of PKA regulatory subunit 1A protein is related to proliferation of human melanoma cells.  |  Mantovani, G., et al. 2008. Oncogene. 27: 1834-43. PMID: 17906691
  7. Human mesenchymal stem cell proliferation is regulated by PGE2 through differential activation of cAMP-dependent protein kinase isoforms.  |  Kleiveland, CR., et al. 2008. Exp Cell Res. 314: 1831-8. PMID: 18395713
  8. 8-Chloro-cyclic AMP and protein kinase A I-selective cyclic AMP analogs inhibit cancer cell growth through different mechanisms.  |  Lucchi, S., et al. 2011. PLoS One. 6: e20785. PMID: 21695205
  9. The cAMP analogs have potent anti-proliferative effects on medullary thyroid cancer cell lines.  |  Dicitore, A., et al. 2016. Endocrine. 51: 101-12. PMID: 25863490
  10. Functional Characterization of PRKAR1A Mutations Reveals a Unique Molecular Mechanism Causing Acrodysostosis but Multiple Mechanisms Causing Carney Complex.  |  Rhayem, Y., et al. 2015. J Biol Chem. 290: 27816-28. PMID: 26405036
  11. 8-Cl-cAMP and PKA I-selective cAMP analogs effectively inhibit undifferentiated thyroid cancer cell growth.  |  Grassi, ES., et al. 2017. Endocrine. 56: 388-398. PMID: 27460006
  12. Elevated Cyclic AMP Inhibits Mycobacterium tuberculosis-Stimulated T-cell IFN-γ Secretion Through Type I Protein Kinase A.  |  Chung, YT., et al. 2018. J Infect Dis. 217: 1821-1831. PMID: 29438524
  13. Differential regulation of oocyte maturation and cumulus expansion in the mouse oocyte-cumulus cell complex by site-selective analogs of cyclic adenosine monophosphate.  |  Downs, SM. and Hunzicker-Dunn, M. 1995. Dev Biol. 172: 72-85. PMID: 7589815
  14. Cyclic AMP-dependent protein kinase (cAK) in human B cells: co-localization of type I cAK (RI alpha 2 C2) with the antigen receptor during anti-immunoglobulin-induced B cell activation.  |  Levy, FO., et al. 1996. Eur J Immunol. 26: 1290-6. PMID: 8647207
  15. Co-regulation of antigen-specific T lymphocyte responses by type I and type II cyclic AMP-dependent protein kinases (cAK).  |  Braun, CM., et al. 1998. Biochem Pharmacol. 56: 871-9. PMID: 9774149
  16. The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3.  |  Lamprecht, G., et al. 1998. J Biol Chem. 273: 29972-8. PMID: 9792717

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

8-PIP-cAMP, 10 µmol

sc-257021
10 µmol
$471.00