8-Oxo-2′-deoxyguanosine-13C,15N2 (CAS 88847-89-6 (unlabeled))
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8-Oxo-2′-deoxyguanosine-13C,15N2 is a stable isotope-labeled analogue of 8-oxo-2′-deoxyguanosine, a nucleoside that serves as an important biomarker for oxidative DNA damage. This compound is enriched with the isotopes carbon-13 (13C) and nitrogen-15 (15N) at specific positions, which makes it an invaluable tool for mass spectrometry-based research. In studies focused on DNA damage and repair mechanisms, 8-Oxo-2′-deoxyguanosine-13C,15N2 is used as an internal standard to accurately quantify the levels of 8-oxo-2′-deoxyguanosine in biological samples. The incorporation of stable isotopes allows for differentiation from endogenous levels of the nucleoside and enhances the precision of detection and quantification. Researchers employ this compound to investigate the impact of oxidative stress on genetic material and to understand the role of oxidative lesions in the etiology of various diseases.
8-Oxo-2′-deoxyguanosine-13C,15N2 (CAS 88847-89-6 (unlabeled)) References
- Daily hydroxyl radical scavenging capacity of mammals. | Ienaga, K., et al. 2014. Drug Discov Ther. 8: 71-5. PMID: 24815581
- Mutagenic Effects of Iron Oxide Nanoparticles on Biological Cells. | Dissanayake, NM., et al. 2015. Int J Mol Sci. 16: 23482-516. PMID: 26437397
- Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells. | Kawanishi, S., et al. 2016. Genes Environ. 38: 26. PMID: 28050219
- Advanced Collaborative Emissions Study Auxiliary Findings on 2007-Compliant Diesel Engines: A Comparison With Diesel Exhaust Genotoxicity Effects Prior to 2007. | Hallberg, LM., et al. 2017. Environ Health Insights. 11: 1178630217714215. PMID: 28659715
- Structural basis of RNA folding and recognition in an AMP-RNA aptamer complex. | Jiang, F., et al. 1996. Nature. 382: 183-6. PMID: 8700212
- Synthesis of 6-Thioguanine and 2, 6-Diaminopurine Nucleosides and Nucleotides from Adenine Counterparts via a Facile Rearrangement in the Base Portion (Nucleosides and Nucleotides. XIX) | Toru Ueda, et al. 1978. Chemical and Pharmaceutical Bulletin. 26: 2122-2127.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-Oxo-2′-deoxyguanosine-13C,15N2, 500 µg | sc-217509 | 500 µg | $1030.00 |