Molecular structure of 8-Nitroguanine, CAS Number: 168701-80-2
8-Nitroguanine (CAS 168701-80-2)
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Alternate Names:
8-NO2-Gua
Application:
8-Nitroguanine is a potent mutagenic product of DNA
CAS Number:
168701-80-2
Purity:
≥95%
Molecular Weight:
196.12
Molecular Formula:
C5H4N6O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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8-Nitroguanine is a potent mutagenic product of DNA formed during inflammation. Specifically, it is the result of a GC to AT induced transversion mutation from the guanine base of DNA. The compound plays an important role in inflammation-related carcinogenesis. Research shows that it has the potential as a biomarker to evaluate carcinogensis and tumor progression.
8-Nitroguanine (CAS 168701-80-2) References
- Importance of guanine nitration and hydroxylation in DNA in vitro and in vivo. | Tuo, J., et al. 2000. Free Radic Biol Med. 29: 147-55. PMID: 10980403
- 8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer. | Hoki, Y., et al. 2007. Oncol Rep. 18: 1165-9. PMID: 17914567
- Immunohistochemical analysis of 8-nitroguanine, a nitrative DNA lesion, in relation to inflammation-associated carcinogenesis. | Hiraku, Y. and Kawanishi, S. 2009. Methods Mol Biol. 512: 3-13. PMID: 19347269
- Formation of 8-nitroguanine due to reaction between guanyl radical and nitrogen dioxide: catalytic role of hydration. | Agnihotri, N. and Mishra, PC. 2010. J Phys Chem B. 114: 7391-404. PMID: 20450217
- SAM and folic acid prevent arsenic-induced oxidative and nitrative DNA damage in human lymphoblast cells by modulating expression of inflammatory and DNA repair genes. | Boonma, T., et al. 2022. Chem Biol Interact. 361: 109965. PMID: 35490796
- Biochemical pathways of 8-aminoguanine production in Sprague-Dawley and Dahl salt-sensitive rats. | Jackson, EK., et al. 2022. Biochem Pharmacol. 201: 115076. PMID: 35551915
- Fast and biphasic 8-nitroguanine production from guanine and peroxynitrite. | Sánchez, AG., et al. 2022. Free Radic Biol Med. 193: 474-484. PMID: 36332879
- Corrigendum to 'Fast and biphasic 8-nitroguanine production from guanine and peroxynitrite' [Free Radic. Biol. Med. 193 (2022) 474-484]. | Sánchez, AG., et al. 2022. Free Radic Biol Med. 193: 656. PMID: 36410073
- Reactive Molecular Dynamics Simulation of the Structural Damages of the B-DNA Induced by the Oxidation/Nitration of Guanine. | Izadi, ME. and Sabzyan, H. 2022. J Phys Chem B. 126: 10347-10359. PMID: 36448964
- In utero arsenic exposure increases DNA damage and gene expression changes in umbilical cord mesenchymal stem cells (UC-MSCs) from newborns as well as in UC-MSC differentiated hepatocytes. | Kantisin, S., et al. 2022. Toxicol Rep. 9: 1728-1741. PMID: 36518486
- Malignant Fibrous Histiocytoma of Scalp after Repeated Infection. | Wu, Y., et al. 2022. Indian J Dermatol. 67: 824-825. PMID: 36998836
- Formation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination. | Yermilov, V., et al. 1995. FEBS Lett. 376: 207-10. PMID: 7498543
- Antioxidant and pro-oxidant actions of flavonoids: effects on DNA damage induced by nitric oxide, peroxynitrite and nitroxyl anion. | Ohshima, H., et al. 1998. Free Radic Biol Med. 25: 1057-65. PMID: 9870559
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-Nitroguanine, 1 mg | sc-202439 | 1 mg | $124.00 |