8-Nitroguanine CAS: 168701-80-2
MF: C5H4N6O3
MW: 196.12
A potent mutagenic product of DNA.

8-Nitroguanine (CAS 168701-80-2)

8-Nitroguanine | CAS 168701-80-2 is rated 5.0 out of 5 by 1.
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Synonym: 8-NO2-Gua
Application: A potent mutagenic product of DNA
CAS Number: 168701-80-2
Purity: ≥95%
Molecular Weight: 196.12
Molecular Formula: C5H4N6O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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8-Nitroguanine is a potent mutagenic product of DNA formed during inflammation. Specifically, it is the result of a GC to AT induced transversion mutation from the guanine base of DNA. The compound plays an important role in inflammation-related carcinogenesis. Research shows that it has the potential as a biomarker to evaluate carcinogensis and tumor progression.


References

1. Yermilov, V., et al. 1995. FEBS Lett. 376: 207-210. PMID: 7498543
2. Ohshima, H., et al. 1998. Free Radic. Biol. Med. 25: 1057-1065. PMID: 9870559
3. Tuo, J., et al. 2000. Free Radic. Biol. Med. 29: 147-155. PMID: 10980403
4. Hoki, Y., et al. 2007. Oncol. Rep. 18: 1165-1169. PMID: 17914567
5. Hiraku, Y. and Kawanishi, S. 2009. Methods Mol. Biol. 512: 3-13. PMID: 19347269
6. Agnihotri, N. and Mishra, P.C. 2010. J Phys Chem B. 114: 7391-7404. PMID: 20450217

Physical State :
Solid
Solubility :
Soluble in DMSO, and water (sonification).
Storage :
Store at -20° C
Melting Point :
260° C (dec.)
Boiling Point :
671.43° C at 760 mmHg (Predicted)
Density :
2.64 g/cm3 (Predicted)
Refractive Index :
n20D 2.17 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4112249
MDL Number :
MFCD02259372
SMILES :
C12=C(NC(=NC1=O)N)N=C(N2)[N+](=O)[O-]

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8-Nitroguanine  Product Citations

See how others have used 8-Nitroguanine. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 29073142  Wu, C. et al. 2017. PLoS ONE. 12: e0183675.

PMID: # 25675904  Lin, HJ. et al. 2015. Int. J. Cardiol. 183: 214-20.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Lin Lin, HJ. et al. (PubMed 25675904) used 8-Nitroguanine as an urinary biomarker of oxidative and nitrosative stress. -SCBT Publication Review
Date published: 2015-05-22
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