Date published: 2026-4-23

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8-Methoxy-2-tetralone (CAS 5309-19-3)

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CAS Number:
5309-19-3
Molecular Weight:
176.21
Molecular Formula:
C11H12O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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8-Methoxy-2-tetralone is slightly soluble in water but highly soluble in organic solutions like ethanol, acetone, and chloroform. It′s used as a standard reference substance for identifying and determining its concentration in different samples. In vitro it is observed to enhance the function of antioxidant enzymes. It′s postulated that 8-Methoxy-2-tetralone acts by influencing various cellular signaling processes, particularly the nuclear factor kappa-B and mitogen-activated protein kinase pathways.


8-Methoxy-2-tetralone (CAS 5309-19-3) References

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  2. Novel transformation of methoxy tetralones during demethylation with boron trifluoride etherate and acetic anhydride  |  Banerjee, A. K., Bedoya, L., Vera, W. J., Melean, C., Mora, H., Laya, M. S., & Alonso, M. Synthetic communications. 34(18): 3399-3408.
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  6. Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT.  |  Gozlan, H., et al. Nature. 305: 140-2. PMID: 6225026
  7. 8-Hydroxy-2-(alkylamino)tetralins and related compounds as central 5-hydroxytryptamine receptor agonists.  |  Arvidsson, LE., et al. 1984. J Med Chem. 27: 45-51. PMID: 6418888
  8. Synthesis of (+)-(R)- and (-)-(S)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)] aminotetralin: new 5-HT1A receptor ligands.  |  Zhuang, ZP., et al. 1995. Chirality. 7: 452-8. PMID: 7577352
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  11. Centrally acting serotonergic agents. Synthesis and structure-activity relationships of C-1- or C-3-substituted derivatives of 8-hydroxy-2-(di-n-propylamino)tetralin.  |  Lin, CH., et al. 1993. J Med Chem. 36: 671-82. PMID: 8459396
  12. Asymmetric reduction of methoxy substituted β-tetralones using transfer hydrogenation  |  Mogi, M., Fuji, K., & Node, M. 2004. Tetrahedron: Asymmetry. 15(23): 3715-3717.
  13. Stereoselective Transaminase‐Mediated Synthesis of Serotonin and Melatonin Receptor Agonists  |  Baud, D., Tappertzhofen, N., Moody, T. S., Ward, J. M., & Hailes, H. C. 2022. Advanced Synthesis & Catalysis. 364(9): 1564-1572.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

8-Methoxy-2-tetralone, 1 g

sc-257018
1 g
$77.00