Molecular structure of 8-Mercaptoguanosine, CAS Number: 26001-38-7
8-Mercaptoguanosine (CAS 26001-38-7)
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Alternate Names:
8-Thioguanosine
Application:
8-Mercaptoguanosine is a guanosine used to stimulate gene activation
CAS Number:
26001-38-7
Molecular Weight:
315.31
Molecular Formula:
C10H13N5O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
8-Mercaptoguanosine, an analogue of guanosine, holds significance as a nucleoside found in all living cells. Researchers have utilized 8-Mercaptoguanosineto investigate the impact of gene expression on cellular processes, specifically focusing on phenomena such as cell growth and differentiation. 8-Mercaptoguanosine is also used as an inhibitor of enzymes such as GTP cyclohydrolase I. Regarding its mechanism of action, 8-Mercaptoguanosinehas demonstrated the ability to bind to specific receptors within the cell, including guanylyl cyclase and adenylate cyclase. The binding of 8-Mercaptoguanosineto these receptors triggers a signaling cascade, instigating subsequent alterations in cellular processes.
8-Mercaptoguanosine (CAS 26001-38-7) References
- Lymphokine-activated killer (LAK) cells. V. 8-Mercaptoguanosine as an IL-2-sparing agent in LAK generation. | Thompson, RA. and Ballas, ZK. 1990. J Immunol. 145: 3524-31. PMID: 1700014
- 8-Mercaptoguanosine-mediated enhancement of in vivo IgG1, IgG2 and IgG3 antibody responses to polysaccharide antigens in normal and xid mice. | Mond, JJ., et al. 1989. Immunopharmacology. 18: 205-12. PMID: 2606651
- Enhancement of T cell proliferation and differentiation by 8-mercaptoguanosine. | Goodman, MG. and Weigle, WO. 1986. Adv Exp Med Biol. 195 Pt B: 443-9. PMID: 2945407
- Interaction between cytokines and 8-mercaptoguanosine in humoral immunity: synergy with interferon. | Goodman, MG. 1987. J Immunol. 139: 142-6. PMID: 3108396
- Demonstration of T-cell-dependent and T-cell-independent components of 8-mercaptoguanosine-mediated adjuvanticity. | Goodman, MG. 1985. Proc Soc Exp Biol Med. 179: 479-86. PMID: 3161082
- 5-Halo-6-phenyl pyrimidinones and 8-substituted guanosines: biological response modifiers with similar effects on B cells. | Wicker, LS., et al. 1988. Cell Immunol. 112: 156-65. PMID: 3257907
- 8-Mercaptoguanosine overcomes unresponsiveness of human neonatal B cells to polysaccharide antigens. | Rijkers, GT., et al. 1988. J Immunol. 141: 2313-6. PMID: 3262655
- Regulation of B-cell differentiation: anti-mu antibodies have opposite effects on differentiation stimulated by bacterial lipopolysaccharide and 8-mercaptoguanosine. | Rollins-Smith, LA. and Lawton, AR. 1988. J Mol Cell Immunol. 4: 9-19. PMID: 3266925
- Regulation of B cell activation by prostaglandins: cell cycle-specific effects on activation by anti-immunoglobulin and 8-mercaptoguanosine. | Goodman, MG. 1986. J Immunol. 137: 3753-7. PMID: 3491148
- Large, activated B cells are the primary B-cell target of 8-bromoguanosine and 8-mercaptoguanosine. | Wicker, LS., et al. 1987. Cell Immunol. 106: 318-29. PMID: 3494541
- Restoration of in vitro responsiveness of xid B cells to TNP-Ficoll by 8-mercaptoguanosine. | Ahmad, A. and Mond, JJ. 1986. J Immunol. 136: 1223-6. PMID: 3511143
- Mechanism of synergy between T cell signals and C8-substituted guanine nucleosides in humoral immunity: B lymphotropic cytokines induce responsiveness to 8-mercaptoguanosine. | Goodman, MG. 1986. J Immunol. 136: 3335-40. PMID: 3514757
- Mechanism of 8-mercaptoguanosine-mediated adjuvanticity: roles of clonal expansion and cellular recruitment. | Goodman, MG. and Weigle, WO. 1984. J Immunol. 133: 2910-4. PMID: 6208266
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-Mercaptoguanosine, 5 mg | sc-221148 | 5 mg | $130.00 | |||
8-Mercaptoguanosine, 25 mg | sc-221148A | 25 mg | $380.00 |