Molecular structure of 8-iso Prostaglandin F2α-d4, CAS Number: 211105-40-7
8-iso Prostaglandin F2α-d4 (CAS 211105-40-7)
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Application:
8-iso Prostaglandin F2α-d4 is a deuterium labeled biochemical
CAS Number:
211105-40-7
Purity:
≥99% deuterated product
Molecular Weight:
358.5
Molecular Formula:
C20H30D4O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
8-iso Prostaglandin F2alpha-d4 (8-iso PGF2alpha) contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of 8-iso PGF2alpha by GC- or LC-mass spectrometry. It is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It circulates in human plasma in two different forms - esterified in LDL phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2alpha level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2alpha levels are about 180-200 pg/mg of creatinine. 8-iso PGF2alpha is a weak TXA2R (TP receptor) agonist in vascular smooth muscle. Conversely, it inhibits platelet aggregation induced by U-46619 (10-6 M) and I-BOP (3 x 10-7 M) with IC50values of 1.6 x 10-6 M and 1.8 x 10-6 M, respectively.
8-iso Prostaglandin F2α-d4 (CAS 211105-40-7) References
- 8-iso-prostaglandin F(2alpha) increases expression of LOX-1 in JAR cells. | Halvorsen, B., et al. 2001. Hypertension. 37: 1184-90. PMID: 11304522
- Quantification of 8-iso-prostaglandin-F(2alpha) and 2,3-dinor-8-iso-prostaglandin-F(2alpha) in human urine using liquid chromatography-tandem mass spectrometry. | Liang, Y., et al. 2003. Free Radic Biol Med. 34: 409-18. PMID: 12566066
- Determination of 8-iso-prostaglandin F(2alpha) in exhaled breath condensate using combination of immunoseparation and LC-ESI-MS/MS. | Syslová, K., et al. 2008. J Chromatogr B Analyt Technol Biomed Life Sci. 867: 8-14. PMID: 18373964
- Measurement of 8-iso-prostaglandin F2alpha in biological fluids as a measure of lipid peroxidation. | Tacconelli, S., et al. 2010. Methods Mol Biol. 644: 165-78. PMID: 20645173
- A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. | Morrow, JD., et al. 1990. Proc Natl Acad Sci U S A. 87: 9383-7. PMID: 2123555
- Noncyclooxygenase oxidative formation of a series of novel prostaglandins: analytical ramifications for measurement of eicosanoids. | Morrow, JD., et al. 1990. Anal Biochem. 184: 1-10. PMID: 2321745
- Determination of 8-iso-prostaglandin F(2α) (8-iso-PGF(2α)) in human urine by ultra-performance liquid chromatography-tandem mass spectrometry. | Noble, S., et al. 2014. J Chromatogr B Analyt Technol Biomed Life Sci. 947-948: 173-8. PMID: 24434562
- Postpartum levels of 8-iso-prostaglandin F2α in plasma and milk phospholipid fractions as biomarker of oxidative stress in first-lactating dairy cows. | Vernunft, A., et al. 2014. Prostaglandins Other Lipid Mediat. 112: 34-8. PMID: 25088446
- Protocols for the measurement of the F2-isoprostane, 15(S)-8-iso-prostaglandin F2α, in biological samples by GC-MS or GC-MS/MS coupled with immunoaffinity column chromatography. | Tsikas, D. and Suchy, MT. 2016. J Chromatogr B Analyt Technol Biomed Life Sci. 1019: 191-201. PMID: 25583542
- Reinterpreting the best biomarker of oxidative stress: The 8-iso-prostaglandin F2α/prostaglandin F2α ratio shows complex origins of lipid peroxidation biomarkers in animal models. | Van't Erve, TJ., et al. 2016. Free Radic Biol Med. 95: 65-73. PMID: 26964509
- Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F2α in wastewater associated with tobacco use. | Ryu, Y., et al. 2016. Sci Rep. 6: 39055. PMID: 27976726
- Packed-Fiber Solid Phase-Extraction Coupled with HPLC-MS/MS for Rapid Determination of Lipid Oxidative Damage Biomarker 8-Iso-Prostaglandin F2α in Urine. | Sun, Y., et al. 2022. Molecules. 27: PMID: 35889290
- Metabolism of 8-iso-prostaglandin F2alpha. | Basu, S. 1998. FEBS Lett. 428: 32-6. PMID: 9645469
- Anaphylaxis increases 8-iso-prostaglandin F2alpha release from guinea-pig lung in vitro. | Montuschi, P., et al. 1999. Eur J Pharmacol. 365: 59-64. PMID: 9988124
Activator of:
TXA2R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-iso Prostaglandin F2α-d4, 25 µg | sc-205174 | 25 µg | $215.00 | |||
8-iso Prostaglandin F2α-d4, 50 µg | sc-205174A | 50 µg | $533.00 |